Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

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Machaczka, MaciejKarolinska Institutet,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden (author)

Allogeneic hematopoietic stem cell transplant with reduced-intensity conditioning for chronic lymphocytic leukemia in Sweden: does donor T-cell engraftment 3 months after transplant predict survival?

Article/chapterEnglish2012

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2012-03-16
Informa Healthcare,2012
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-82050
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-82050URI
https://doi.org/10.3109/10428194.2012.666661DOI
https://lup.lub.lu.se/record/3147742URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:125141891URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182014URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

Notes

Thirty-eight adult patients with chronic lymphocytic leukemia (CLL) underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplant (allo-SCT) in Sweden between 1999 and 2007. The cumulative incidences of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD were 29% and 47%, respectively. Rates of non-relapse mortality, progression-free survival (PFS) and overall survival (OS) were 18%, 47% and 74% at 1 year, and 21%, 25% and 45% at 5 years, respectively. T-cell chimerism after transplant was measured in 31 out of 34 patients (91%) surviving beyond day + 100. Seventeen patients achieved andgt; 90% donor T-cell engraftment at 3 months after allo-SCT and, compared with the 12 patients with andlt;= 90% donor T-cell engraftment, they showed favorable PFS at 1 year (82% vs. 33%, p = 0.002) and better long-term PFS and OS (p = 0.002 and 0.046, respectively). Donor T-cell engraftment of andgt; 90% at 3 months after RIC allo-SCT for CLL seems to predict favorable short-term and long-term outcome.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Allogeneic stem cell transplant
chronic lymphocytic leukemia
T-cell
donor engraftment
MEDICINE
MEDICIN
Allogeneic stem cell transplant
chronic lymphocytic leukemia
T-cell
donor engraftment

Added entries (persons, corporate bodies, meetings, titles ...)

Johansson, Jan-ErikSahlgrens University Hospital, Sweden (author)
Remberger, MatsKarolinska Institute, Sweden (author)
Hallböök, HeleneUppsala universitet,Karolinska Institutet,Hematologi,University of Uppsala Hospital, Sweden(Swepub:uu)helehall (author)
Malm, ClaesÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US(Swepub:liu)clama59 (author)
Lazarevic, VladimirLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden(Swepub:lu)med-lzv (author)
Wahlin, AndersUmeå University, Sweden (author)
Omar, HamdyKarolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden (author)
Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden(Swepub:lu)stem-gju (author)
Kimby, EvaKarolinska Institutet,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden (author)
Hägglund, HansUppsala universitet,Hematologi,Karolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden(Swepub:uu)hanha689 (author)
Karolinska InstitutetKarolinska University Hospital Huddinge, Sweden Karolinska Institute, Sweden (creator_code:org_t)

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In:Leukemia and Lymphoma: Informa Healthcare53:9, s. 1699-17051042-81941029-2403

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