Bladder Wash Cytology at Diagnosis of Ta-T1 Bladder Cancer Is Predictive for Recurrence and Progression

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Jancke, GeorgLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)

Bladder Wash Cytology at Diagnosis of Ta-T1 Bladder Cancer Is Predictive for Recurrence and Progression

Article/chapterEnglish2012

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Elsevier,2012
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LIBRIS-ID:oai:DiVA.org:liu-82061
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-82061URI
https://doi.org/10.1016/j.urology.2012.04.049DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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OBJECTIVE To evaluate the effect of the bladder wash cytology finding at the primary diagnosis of Stage Ta-T1 urinary bladder cancer on recurrence and progression. less thanbrgreater than less thanbrgreater thanMETHODS The clinical and pathologic characteristics of all patients with primary Stage Ta-T1 urinary bladder cancer were prospectively registered. The data were divided according to the bladder wash cytology results at diagnosis. Multivariate analyses were performed to determine the influence of bladder wash cytology on recurrence and progression. less thanbrgreater than less thanbrgreater thanRESULTS The analysis included 768 evaluable patients with a mean follow-up of 60 months. Recurrence was observed in 478 patients (62%) and progression in 71 (9%). High-grade malignant bladder wash cytology was predictive for recurrence and progression (P andlt; .001 and P = .036, respectively). Other factors affecting recurrence were missing bladder wash cytology data, tumors size 16-30 mm and andgt;30 mm, Stage T1 tumor category, and multiplicity (P = .008, P = .006, P andlt; .001, P = .002, and P andlt; .001, respectively). Progression was also associated with T1 tumor category, local recurrence, and primary concomitant carcinoma in situ (P andlt; .001, P andlt; .001, and P = .024, respectively). less thanbrgreater than less thanbrgreater thanCONCLUSION High-grade malignant bladder wash cytology at the primary diagnosis was predictive for recurrence and progression. This could be taken into account in designing future follow-up schedules.

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MEDICINE
MEDICIN

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Rosell, JohanÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Regionalt cancercentrum(Swepub:liu)johro19 (author)
Chebil, GunillaCounty Hospital, Helsingborg, Sweden (author)
Jahnson, StaffanÖstergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Urologiska kliniken i Östergötland(Swepub:liu)staja74 (author)
Linköpings universitetInstitutionen för klinisk och experimentell medicin (creator_code:org_t)

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In:Urology: Elsevier80:3, s. 625-6310090-42951527-9995

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By the author/editor: Jancke, Georg; Rosell, Johan; Chebil, Gunilla; Jahnson, Staffan

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