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LTBP-2 confers plei...
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Chen, HanHong Kong University of Science and Technology, Peoples R China
(author)
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Elsevier,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-84878
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84878URI
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https://doi.org/10.1016/j.canlet.2012.06.005DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125300182URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||
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This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.
Subject headings and genre
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Latent transforming growth factor beta binding protein 2 (LTBP-2)
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Nasopharyngeal carcinoma (NPC)
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Anti-angiogenesis
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Tumor suppression
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Tumor cell dormancy
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Metastatic growth
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TECHNOLOGY
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TEKNIKVETENSKAP
Added entries (persons, corporate bodies, meetings, titles ...)
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Mun Yee Ko, JosephineUniversity of Hong Kong, Peoples R China
(author)
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Chun Lam Wong, VictorUniversity of Hong Kong, Peoples R China
(author)
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Hyytiainen, MarkoUniversity of Helsinki, Finland University of Helsinki, Finland
(author)
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Keski-Oja, JormaUniversity of Helsinki, Finland University of Helsinki, Finland
(author)
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Chua, DanielUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China Hong Kong Sanat and Hospital, Peoples R China
(author)
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Nicholls, John MUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(author)
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Man Fung Cheung, FlorenceUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
(author)
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Wing Mui Lee, AnneUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
(author)
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Lai-Wan Kwong, DoraUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(author)
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Man Chiu, PuiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(author)
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Zabarovsky, Eugene RLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
(author)
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Wah Tsao, SaiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(author)
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Tao, QianChinese University of Hong Kong, Peoples R China
(author)
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Kan, RebeccaUniversity of Hong Kong, Peoples R China
(author)
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Ho Kin Chan, StephenUniversity of Hong Kong, Peoples R China
(author)
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Stanbridge, Eric JUniversity of Calif Irvine, CA 92697 USA
(author)
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Li Lung, MariaUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
(author)
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Hong Kong University of Science and Technology, Peoples R ChinaUniversity of Hong Kong, Peoples R China
(creator_code:org_t)
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In:Cancer Letters: Elsevier325:1, s. 89-980304-38351872-7980
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