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  • Chen, HanHong Kong University of Science and Technology, Peoples R China (author)

LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-84878
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84878URI
  • https://doi.org/10.1016/j.canlet.2012.06.005DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125300182URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||
  • This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.

Subject headings and genre

  • Latent transforming growth factor beta binding protein 2 (LTBP-2)
  • Nasopharyngeal carcinoma (NPC)
  • Anti-angiogenesis
  • Tumor suppression
  • Tumor cell dormancy
  • Metastatic growth
  • TECHNOLOGY
  • TEKNIKVETENSKAP

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mun Yee Ko, JosephineUniversity of Hong Kong, Peoples R China (author)
  • Chun Lam Wong, VictorUniversity of Hong Kong, Peoples R China (author)
  • Hyytiainen, MarkoUniversity of Helsinki, Finland University of Helsinki, Finland (author)
  • Keski-Oja, JormaUniversity of Helsinki, Finland University of Helsinki, Finland (author)
  • Chua, DanielUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China Hong Kong Sanat and Hospital, Peoples R China (author)
  • Nicholls, John MUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China (author)
  • Man Fung Cheung, FlorenceUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China (author)
  • Wing Mui Lee, AnneUniversity of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China (author)
  • Lai-Wan Kwong, DoraUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China (author)
  • Man Chiu, PuiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China (author)
  • Zabarovsky, Eugene RLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)
  • Wah Tsao, SaiUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China (author)
  • Tao, QianChinese University of Hong Kong, Peoples R China (author)
  • Kan, RebeccaUniversity of Hong Kong, Peoples R China (author)
  • Ho Kin Chan, StephenUniversity of Hong Kong, Peoples R China (author)
  • Stanbridge, Eric JUniversity of Calif Irvine, CA 92697 USA (author)
  • Li Lung, MariaUniversity of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China (author)
  • Hong Kong University of Science and Technology, Peoples R ChinaUniversity of Hong Kong, Peoples R China (creator_code:org_t)

Related titles

  • In:Cancer Letters: Elsevier325:1, s. 89-980304-38351872-7980

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