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LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma

Chen, Han (author)
Hong Kong University of Science and Technology, Peoples R China
Mun Yee Ko, Josephine (author)
University of Hong Kong, Peoples R China
Chun Lam Wong, Victor (author)
University of Hong Kong, Peoples R China
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Hyytiainen, Marko (author)
University of Helsinki, Finland University of Helsinki, Finland
Keski-Oja, Jorma (author)
University of Helsinki, Finland University of Helsinki, Finland
Chua, Daniel (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China Hong Kong Sanat and Hospital, Peoples R China
Nicholls, John M (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
Man Fung Cheung, Florence (author)
University of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
Wing Mui Lee, Anne (author)
University of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
Lai-Wan Kwong, Dora (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
Man Chiu, Pui (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
Zabarovsky, Eugene R (author)
Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
Wah Tsao, Sai (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
Tao, Qian (author)
Chinese University of Hong Kong, Peoples R China
Kan, Rebecca (author)
University of Hong Kong, Peoples R China
Ho Kin Chan, Stephen (author)
University of Hong Kong, Peoples R China
Stanbridge, Eric J (author)
University of Calif Irvine, CA 92697 USA
Li Lung, Maria (author)
University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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 (creator_code:org_t)
Elsevier, 2012
2012
English.
In: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 325:1, s. 89-98
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.

Keyword

Latent transforming growth factor beta binding protein 2 (LTBP-2)
Nasopharyngeal carcinoma (NPC)
Anti-angiogenesis
Tumor suppression
Tumor cell dormancy
Metastatic growth
TECHNOLOGY
TEKNIKVETENSKAP

Publication and Content Type

ref (subject category)
art (subject category)

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