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LTBP-2 confers plei...
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
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- Chen, Han (författare)
- Hong Kong University of Science and Technology, Peoples R China
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- Mun Yee Ko, Josephine (författare)
- University of Hong Kong, Peoples R China
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- Chun Lam Wong, Victor (författare)
- University of Hong Kong, Peoples R China
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- Hyytiainen, Marko (författare)
- University of Helsinki, Finland University of Helsinki, Finland
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- Keski-Oja, Jorma (författare)
- University of Helsinki, Finland University of Helsinki, Finland
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- Chua, Daniel (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China Hong Kong Sanat and Hospital, Peoples R China
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- Nicholls, John M (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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- Man Fung Cheung, Florence (författare)
- University of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
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- Wing Mui Lee, Anne (författare)
- University of Hong Kong, Peoples R China Pamela Youde Nethersole Eastern Hospital, Peoples R China
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- Lai-Wan Kwong, Dora (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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- Man Chiu, Pui (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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- Zabarovsky, Eugene R (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Wah Tsao, Sai (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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- Tao, Qian (författare)
- Chinese University of Hong Kong, Peoples R China
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- Kan, Rebecca (författare)
- University of Hong Kong, Peoples R China
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- Ho Kin Chan, Stephen (författare)
- University of Hong Kong, Peoples R China
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- Stanbridge, Eric J (författare)
- University of Calif Irvine, CA 92697 USA
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- Li Lung, Maria (författare)
- University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China University of Hong Kong, Peoples R China
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(creator_code:org_t)
- Elsevier, 2012
- 2012
- Engelska.
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Ingår i: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 325:1, s. 89-98
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.
Nyckelord
- Latent transforming growth factor beta binding protein 2 (LTBP-2)
- Nasopharyngeal carcinoma (NPC)
- Anti-angiogenesis
- Tumor suppression
- Tumor cell dormancy
- Metastatic growth
- TECHNOLOGY
- TEKNIKVETENSKAP
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Chen, Han
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Mun Yee Ko, Jose ...
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Chun Lam Wong, V ...
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Hyytiainen, Mark ...
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Keski-Oja, Jorma
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Chua, Daniel
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Nicholls, John M
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Man Fung Cheung, ...
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Wing Mui Lee, An ...
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Lai-Wan Kwong, D ...
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Man Chiu, Pui
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Zabarovsky, Euge ...
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Wah Tsao, Sai
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Tao, Qian
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Kan, Rebecca
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Ho Kin Chan, Ste ...
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Stanbridge, Eric ...
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Li Lung, Maria
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Cancer Letters
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet