SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:liu-84885"
 

Search: onr:"swepub:oai:DiVA.org:liu-84885" > Lipopolysaccharide-...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Engström, LindaLinköpings universitet,Cellbiologi,Hälsouniversitetet (author)

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Endocrine Society,2012
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-84885
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84885URI
  • https://doi.org/10.1210/en.2012-1375DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125307467URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council|7879|Swedish Cancer Foundation|100533|Swedish Brain Foundation||Gustav V:s 80-ars Fond||
  • Immune-induced prostaglandin E2 (PGE2) synthesis is critical for fever and other centrally elicited disease symptoms. The production of PGE2 depends on cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (mPGES-1), but the identity of the cells involved has been a matter of controversy. We generated mice expressing mPGES-1 either in cells of hematopoietic or nonhematopoietic origin. Mice lacking mPGES-1 in hematopoietic cells displayed an intact febrile response to lipopolysaccharide, associated with elevated levels of PGE2 in the cerebrospinal fluid. In contrast, mice that expressed mPGES-1 only in hematopoietic cells, although displaying elevated PGE2 levels in plasma but not in the cerebrospinal fluid, showed no febrile response to lipopolysaccharide, thus pointing to the critical role of brain-derived PGE2 for fever. Immunohistochemical stainings showed that induced cyclooxygenase-2 expression in the brain exclusively occurred in endothelial cells, and quantitative PCR analysis on brain cells isolated by flow cytometry demonstrated that mPGES-1 is induced in endothelial cells and not in vascular wall macrophages. Similar analysis on liver cells showed induced expression in macrophages and not in endothelial cells, pointing at the distinct role for brain endothelial cells in PGE2 synthesis. These results identify the brain endothelial cells as the PGE2-producing cells critical for immune-induced fever.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ruud, JohanLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)johru61 (author)
  • Eskilsson, AnnaLinköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet(Swepub:liu)annes38 (author)
  • Larsson, AndersLinköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet(Swepub:liu)andla36 (author)
  • Mackerlova, LudmilaLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)ludma70 (author)
  • Kugelberg, UnnLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)
  • Qian, HongKarolinska Institutet,Linköpings universitet,Experimentell hematologi,Hälsouniversitetet(Swepub:liu)honqi03 (author)
  • Vasilache, Ana MariaLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)anava88 (author)
  • Larsson, PeterLinköpings universitet,Medicinsk radiofysik,Hälsouniversitetet(Swepub:liu)petla27 (author)
  • Engblom, DavidLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)daven69 (author)
  • Sigvardsson, MikaelLinköpings universitet,Experimentell hematologi,Hälsouniversitetet(Swepub:liu)miksi32 (author)
  • Jönsson, Jan-IngvarLinköpings universitet,Experimentell hematologi,Hälsouniversitetet(Swepub:liu)janjo86 (author)
  • Blomqvist, AndersLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)andbl47 (author)
  • Linköpings universitetCellbiologi (creator_code:org_t)

Related titles

  • In:Endocrinology: Endocrine Society153:10, s. 4849-48610013-72271945-7170

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view