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Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies

Cardwell, Chris R (författare)
Queens University of Belfast, North Ireland
Stene, Lars C (författare)
Norwegian Institute Public Heatlh, Norway Oslo University Hospital, Norway
Ludvigsson, Johnny (författare)
Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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Rosenbauer, Joachim (författare)
University of Dusseldorf, Germany
Cinek, Ondrej (författare)
Charles University of Prague, Czech Republic University Hospital Motol, Czech Republic
Svensson, Jannet (författare)
Herlev University Hospital, Denmark
Perez-Bravo, Francisco (författare)
University of Chile, Chile
Memon, Anjum (författare)
Brighton and Sussex Medical School and NHS Brighton and Hove, England
Gimeno, Suely G (författare)
University of Federal Sao Paulo, Brazil
Wadsworth, Emma J K (författare)
Cardiff University, Wales
Strotmeyer, Elsa S (författare)
University of Pittsburgh, PA USA
Goldacre, Michael J (författare)
University of Oxford, England
Radon, Katja (författare)
Hospital Ludwig Maximilian University of Munich, Germany
Chuang, Lee-Ming (författare)
National Taiwan University Hospital, Taiwan
Parslow, Roger C (författare)
University of Leeds, England
Chetwynd, Amanda (författare)
University of Lancaster, England
Karavanaki, Kyriaki (författare)
University of Athens, Greece
Brigis, Girts (författare)
Riga Stradins University, Latvia
Pozzilli, Paolo (författare)
University of Campus Biomed, Italy
Urbonaite, Brone (författare)
Lithuanian University of Health Science, Lithuania
Schober, Edith (författare)
Medical University of Vienna, Austria
Devoti, Gabriele (författare)
University of Salento, Italy
Sipetic, Sandra (författare)
University of Belgrade, Serbia
Joner, Geir (författare)
University of Oslo, Norway Oslo University Hospital, Norway
Ionescu-Tirgoviste, Constantin (författare)
N Paulescu Institute Diabet, Romania
de Beaufort, Carine E (författare)
Clin Pediat Luxembourg, Luxembourg
Harrild, Kirsten (författare)
University of Aberdeen, Scotland
Benson, Victoria (författare)
University of Oxford, England
Savilahti, Erkki (författare)
University of Helsinki, Finland
Ponsonby, Anne-Louise (författare)
Royal Childrens Hospital, Australia
Salem, Mona (författare)
Ain Shams University, Egypt
Rabiei, Samira (författare)
Shahid Beheshti University of Medical Science and Health Serv, Iran
C Patterson, Chris (författare)
Queens University of Belfast, North Ireland
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 (creator_code:org_t)
2012-10-13
2012
Engelska.
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 35:11, s. 2215-2225
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE-To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. less thanbrgreater than less thanbrgreater thanRESEARCH DESIGN AND METHODS-Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. less thanbrgreater than less thanbrgreater thanRESULTS-Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for andgt;2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for andgt;3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for andgt;2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or andgt;3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I-2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for andgt;2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I-2 = 0%). Adjustments for potential confounders altered these estimates very little. less thanbrgreater than less thanbrgreater thanCONCLUSIONS-The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies.

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MEDICINE
MEDICIN

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