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  • Cardwell, Chris RQueens University of Belfast, North Ireland (författare)

Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-10-13
  • American Diabetes Association,2012
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-86376
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86376URI
  • https://doi.org/10.2337/dc12-0438DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Institutes of Health|R01-DK-46498R01-DK-42316|Chinese Foundation of Health||Department of Health, Executive Yuan, Republic of China|DOH91-TD1167|Ministry for Science and Technology of the Republic of Serbia|175042|German Research Foundation|HE 234/1-1|Research Council of Norway|148359/330|
  • OBJECTIVE-To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. less thanbrgreater than less thanbrgreater thanRESEARCH DESIGN AND METHODS-Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. less thanbrgreater than less thanbrgreater thanRESULTS-Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for andgt;2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for andgt;3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for andgt;2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or andgt;3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I-2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for andgt;2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I-2 = 0%). Adjustments for potential confounders altered these estimates very little. less thanbrgreater than less thanbrgreater thanCONCLUSIONS-The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies.

Ämnesord och genrebeteckningar

  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stene, Lars CNorwegian Institute Public Heatlh, Norway Oslo University Hospital, Norway (författare)
  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (författare)
  • Rosenbauer, JoachimUniversity of Dusseldorf, Germany (författare)
  • Cinek, OndrejCharles University of Prague, Czech Republic University Hospital Motol, Czech Republic (författare)
  • Svensson, JannetHerlev University Hospital, Denmark (författare)
  • Perez-Bravo, FranciscoUniversity of Chile, Chile (författare)
  • Memon, AnjumBrighton and Sussex Medical School and NHS Brighton and Hove, England (författare)
  • Gimeno, Suely GUniversity of Federal Sao Paulo, Brazil (författare)
  • Wadsworth, Emma J KCardiff University, Wales (författare)
  • Strotmeyer, Elsa SUniversity of Pittsburgh, PA USA (författare)
  • Goldacre, Michael JUniversity of Oxford, England (författare)
  • Radon, KatjaHospital Ludwig Maximilian University of Munich, Germany (författare)
  • Chuang, Lee-MingNational Taiwan University Hospital, Taiwan (författare)
  • Parslow, Roger CUniversity of Leeds, England (författare)
  • Chetwynd, AmandaUniversity of Lancaster, England (författare)
  • Karavanaki, KyriakiUniversity of Athens, Greece (författare)
  • Brigis, GirtsRiga Stradins University, Latvia (författare)
  • Pozzilli, PaoloUniversity of Campus Biomed, Italy (författare)
  • Urbonaite, BroneLithuanian University of Health Science, Lithuania (författare)
  • Schober, EdithMedical University of Vienna, Austria (författare)
  • Devoti, GabrieleUniversity of Salento, Italy (författare)
  • Sipetic, SandraUniversity of Belgrade, Serbia (författare)
  • Joner, GeirUniversity of Oslo, Norway Oslo University Hospital, Norway (författare)
  • Ionescu-Tirgoviste, ConstantinN Paulescu Institute Diabet, Romania (författare)
  • de Beaufort, Carine EClin Pediat Luxembourg, Luxembourg (författare)
  • Harrild, KirstenUniversity of Aberdeen, Scotland (författare)
  • Benson, VictoriaUniversity of Oxford, England (författare)
  • Savilahti, ErkkiUniversity of Helsinki, Finland (författare)
  • Ponsonby, Anne-LouiseRoyal Childrens Hospital, Australia (författare)
  • Salem, MonaAin Shams University, Egypt (författare)
  • Rabiei, SamiraShahid Beheshti University of Medical Science and Health Serv, Iran (författare)
  • C Patterson, ChrisQueens University of Belfast, North Ireland (författare)
  • Queens University of Belfast, North IrelandNorwegian Institute Public Heatlh, Norway Oslo University Hospital, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association35:11, s. 2215-22250149-59921935-5548

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