Redox events in HTLV-1 tax-induced apoptotic T-cell death

Chlichlia, K.Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany (author)

A number of studies implicate reactive oxygen intermediates in the induction of DNA damage and apoptosis. Recent studies suggest that the human T-cell leukemia virus type I (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. Activation of the T-cell receptor/CD3 pathway enhances the Tax-mediated oxidative and apoptotic effects. Tax-mediated apoptosis and oxidative stress as well as activation of nuclear factor-kappaB can be potently suppressed by antioxidants. This review focuses on Tax-dependent changes in the intracellular redox status and their role in Tax-mediated DNA damage and apoptosis. The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
dna-repair
gene-expression
human thioredoxin
leukemia-virus
nf-kappa-b
oxidative stress
prooxidant state
Signaling pathway
transcription factors
virus type-i

Los, Marek JanDepartment of Immunology and Cell Biology, University of Muenster, Roentgenstr. 21, D-48149 Muenster, Germany(Swepub:liu)marlo14 (author)
Schulze-Osthoff, KlausDepartment of Immunology and Cell Biology, University of Muenster, Roentgenstr. 21, D-48149 Muenster, Germany (author)
Gazzolo, L.INSERM U412, Ecole Normale S périeure de Lyon, 69367 Lyon, Cedex 07, France (author)
Schirrmacher, V.Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany (author)
Khazaie, K.Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany; 4Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, U.S.A. (author)
Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, GermanyDepartment of Immunology and Cell Biology, University of Muenster, Roentgenstr. 21, D-48149 Muenster, Germany (creator_code:org_t)

In:Antioxidants and Redox Signaling: Mary Ann Liebert, Inc. publishers4:3, s. 471-4771523-08641557-7716

By the author/editor: Chlichlia, K.; Los, Marek Jan; Schulze-Osthoff, ...; Gazzolo, L.; Schirrmacher, V.; Khazaie, K.

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

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