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An Fcγ receptor I (...
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Grage-Griebenow, E.Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
(author)
An Fcγ receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells
- Article/chapterEnglish1997
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Wiley,1997
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-87072
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-87072URI
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https://doi.org/10.1002/eji.1830270934DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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It has been demonstrated that in monocyte/T cell co-cultures activated with recall antigens, cytotoxic T cells were generated which are able to reduce the number of antigen-presenting monocytes. In previous studies we could show that a minor subset of monocytes, the Fc gamma receptor I-negative (CD64(-)) monocytes, exhibits significantly higher antigen-presenting capacity than the main population of monocytes (> 90%) which are Fc gamma receptor I-positive (CD64(+)). Therefore, we addressed the question whether they are also differentially susceptible to T cell-mediated killing. In the present study we demonstrate that the CD64(-) monocyte subset is more resistant to killing by antigen-activated T cells than CD64(+) monocytes, as indicated by a higher viability and recovery of CD64(-) monocytes. This mechanism involves CD95 (Fas) antigen, since monocyte death in co-cultures with antigen-activated T cells could be partially reduced by blocking anti-Fas monoclonal antibodies (mAb). In agreement with this finding, although CD95 antigen was expressed on CD64(+) and CD64(-) monocytes at comparable levels, killing of CD64(-) monocytes by activating anti-Fas mAb was lower than of CD64(+) monocytes.
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Baran, J.Jagiellonian University, Institute of Molecular Biology, Cracow, Poland
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Loppnow, H.Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
(author)
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Los, Marek JanDeutsches Krebsforschungs-zentrum, Heidelberg, Germany(Swepub:liu)marlo14
(author)
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Ernst, M.Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
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Flad, H. D.Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
(author)
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Pryjma, J.Jagiellonian University, Institute of Molecular Biology, Cracow, Poland
(author)
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Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, GermanyJagiellonian University, Institute of Molecular Biology, Cracow, Poland
(creator_code:org_t)
Related titles
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In:European Journal of Immunology: Wiley27:9, s. 2358-23650014-29801521-4141
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