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Requirement of an I...
Requirement of an Ice/Ced-3 Protease for Fas/Apo-1-Mediated Apoptosis
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- Los, Marek Jan (author)
- Institute of Biochemistry, Albert-Ludwigs-University, Hermann-Heder-Strasse 7, D79104 Freiburg im Breisgau, Germany
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- Vandecraen, M. (author)
- Laboratory of Molecular Biology, University of Ghent, Ghent, Belgium
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- Penning, Lc (author)
- Laboratory of Molecular Biology, University of Ghent, Ghent, Belgium
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- Schenk, H. (author)
- Divisions of Immunochemistry § Divisions of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
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- Westendorp, M. (author)
- Divisions of Immunochemistry § Divisions of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
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- Baeuerle, Pa (author)
- Institute of Biochemistry, Albert-Ludwigs-University, Hermann-Heder-Strasse 7, D79104 Freiburg im Breisgau, Germany
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- Droge, W. (author)
- Divisions of Immunochemistry § Divisions of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
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- Krammer, Peter (author)
- Divisions of Immunochemistry § Divisions of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
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- Fiers, W. (author)
- Laboratory of Molecular Biology, University of Ghent, Ghent, Belgium
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- Schulze-Osthoff, Klaus (author)
- Institute of Biochemistry, Albert-Ludwigs-University, Hermann-Heder-Strasse 7, D79104 Freiburg im Breisgau, Germany
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(creator_code:org_t)
- Springer Science and Business Media LLC, 1995
- 1995
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 375:6526, s. 81-83
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Abstract
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- THE Fas/APO-1 receptor is one of the major regulators of apoptosis(1-7). We report here that Fas/APO-1-mediated apoptosis requires the activation of a new class of cysteine proteases, including interleukin-1 beta-converting enzyme (ICE)(8-10) which are homologous to the product of the Caenorhabditis elegans cell-death gene ced-3 (refs 11, 12). Triggering of Fas/APO-1 rapidly stimulated the proteolytic activity of ICE. Overexpression of ICE, achieved by electroporation and microinjection, strongly potentiated Fas/APO-1-mediated cell death. In addition, inhibition of ICE activity by protease inhibitors, as well as by transient expression of the pox virus-derived serpin inhibitor CrmA or an antisense ICE construct, substantially suppressed Fas/APO-1-triggered cell death. We conclude that activation of ICE or an ICE-related protease is a critical event in Fas/APO-1-mediated cell death.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- cell-surface antigen
- death gene ced-3
- fas
- induction
- interleukin-1-beta converting enzyme
- molecular-cloning
- monoclonal-antibody
- receptor
- tumor-necrosis-factor
- virus encodes
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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- By the author/editor
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Los, Marek Jan
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Vandecraen, M.
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Penning, Lc
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Schenk, H.
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Westendorp, M.
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Baeuerle, Pa
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show more...
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Droge, W.
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Krammer, Peter
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Fiers, W.
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Schulze-Osthoff, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Nature
- By the university
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Linköping University