Sökning: WFRF:(Schulze W)
> (1995-1999) >
Hydrogen-Peroxide a...
Hydrogen-Peroxide as a Potent Activator of T-Lymphocyte Functions
-
- Los, Marek Jan (författare)
- Division of Immunochemistry, University of Freiburg, Freiburg; Division of Immunogenetics, University of Freiburg, Freiburg
-
- Droge, W. (författare)
- Division of Immunochemistry, University of Freiburg, Freiburg
-
- Stricker, K. (författare)
- Deutsches Krebsforschungszentrum, Heidelberg and Institute of Biochemistry, University of Freiburg, Freiburg
-
visa fler...
-
- Baeuerle, Pa (författare)
- Division of Immunogenetics, University of Freiburg, Freiburg
-
- Schulze-Osthoff, Klaus (författare)
- Division of Immunochemistry, University of Freiburg, Freiburg ; Division of Immunogenetics, University of Freiburg, Freiburg; Deutsches Krebsforschungszentrum, Heidelberg and Institute of Biochemistry, University of Freiburg, Freiburg
-
visa färre...
-
(creator_code:org_t)
- Wiley, 1995
- 1995
- Engelska.
-
Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 25:1, s. 159-165
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
http://liu.diva-port...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- During inflammatory processes infiltrating cells produce large amounts of reactive oxygen intermediates (ROI). Increasing evidence suggests that ROI besides being cytotoxic may act as important mediators influencing various cellular and immunological processes. In this study, we have investigated the effects of hydrogen peroxide on several aspects of lymphocyte activation. In ESb-L T lymphoma cells, micromolar concentrations of hydrogen peroxide rapidly induced activation of the transcription factor NF-kappa B, whereas DNA-binding activity of the transcription factor AP-1 was virtually not affected. In addition, hydrogen peroxide induced early gene expression of interleukin-2 (IL-2) and the IL-2 receptor alpha chain. The stimulation of IL-2 expression was found to be conferred by a kappa B-like cis-regulatory region within the IL-2 gene promoter. In contrast to these activating effects, addition of hydrogen peroxide was largely inhibitory on cell proliferation which is consistent with a general requirement of thiol compounds for lymphocyte proliferation. However, hydrogen peroxide significantly increased T cell proliferation when applied for a short period under reducing conditions. These data indicate that ROI may act as an important competence signal in T lymphocytes inducing early gene expression as well as cell proliferation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- antioxidants
- cell-growth
- expression
- free-radicals
- gene
- inhibition
- interleukin-2
- nf-kappa-b
- Proliferation
- reactive oxygen intermediates
- t cell
- transcription
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas