WFRF:(Jancke Georg)
Search: WFRF:(Jancke Georg) > (2010-2014) > Aspects of Recurren...
- 1 of 5
- Previous record
- Next record
- To hitlist
- Jancke, Georg,1970-Linköpings universitet,Urologi,Hälsouniversitetet (author)
Aspects of Recurrence and Progression in Ta/T1 Urinary Bladder Cancer
- BookEnglish2013
Publisher, publication year, extent ...
- Linköping :Linköping University Electronic Press,2013
- 81 s.
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-89146
- ISBN:9789175197388
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89146URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Series
- Linköping University Medical Dissertations,0345-0082 ;1344
Notes
- Aims: To evaluate different aspects of recurrence and, when appropriate, progression in primary Ta/T1 urinary bladder cancer.Patients and methods: All evaluable patients diagnosed with primary Ta/T1 urinary bladder cancer in Linköping and Norrköping between 1992 and 2007 were included prospectively in the study cohort. Histopathology results were classified according to the TNM system and were reviewed by a reference pathologist using the WHO 1999 criteria (except in the studies reported in Papers I and IV). Risk factors for local recurrence were evaluated using data from the period 1992–2001 (Paper I). Tumour size (Paper II) and bladder wash cytology (Paper III) at primary diagnosis were assessed regarding the impact on recurrence and progression, and tumour presence in the marginal resection in primary and recurrent Ta/T1 bladder cancer was investigated considering effects on recurrence in patients treated between 2001 and 2010 (Paper IV). Furthermore, surgical experience measured as training status (resident or specialist) and surgical volume (both during the study period and lifetime) were analysed regarding their influence on recurrence and progression (Paper V).Results: Tumour size > 30 mm (p < 0.001) and multiplicity (p = 0.021) were significantly associated with local recurrence (Paper I). Tumour sizes 16–30 mm and > 30 mm were correlated with recurrence (p = 0.003 and p < 0.001, respectively) but not with progression (Paper II). High-grade malignant bladder wash cytology proved to be predictive of both recurrence (p < 0.001) and progression (p = 0.036) as was shown in Paper III. A tumour-positive marginal resection was related to overall (p < 0.001) and local (p < 0.001) recurrence (Paper IV). Transurethral resection of bladder tumours performed by residents was associated with recurrence (p = 0.004) but not with progression. No differences in relation to either recurrence or progression were found for the surgical volume approach at the chosen cut-offs (Paper V).Conclusions: The present studies identified new risk factors for recurrence (tumours > 15 mm, high-grade bladder wash cytology at diagnosis, tumour-positive marginal resection, and surgery performed by residents) and progression (local recurrence and high-grade malignant bladder wash cytology at diagnosis), which in the future may be integrated into follow-up schedules or risk profiles for patients with Ta/T1 urinary bladder cancer.
Added entries (persons, corporate bodies, meetings, titles ...)
- Jahnson, Staffan,Associate ProfessorÖstergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Urologiska kliniken i Östergötland(Swepub:liu)staja74 (thesis advisor)
- Adolfsson, Jan,Associate ProfessorDivision of Urology, Karolinska Institute, Stockholm (opponent)
- Linköpings universitetUrologi (creator_code:org_t)
Internet link
Find in a library
- Aspects of Recurrence and Progression in Ta/T1 Urinary Bladder Cancer (Search the publication in LIBRIS)
To the university's database
- 1 of 5
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jancke, Georg, 1 ...
- Jahnson, Staffan ...
- Adolfsson, Jan, ...
- Parts in the series
- Linköping Univer ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
