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  • Cosedis Nielsen, JensAarhus University Hospital, Denmark (author)

Radiofrequency Ablation as Initial Therapy in Paroxysm Atrial Fibrillation

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Massachusetts Medical Society,2012
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-89595
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89595URI
  • https://doi.org/10.1056/NEJMoa1113566DOI
  • https://lup.lub.lu.se/record/3174040URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Danish Heart Foundation|05-4-B284-A466-22237|Biosense Webster||Finnish Foundation for Cardiovascular Research||Biotronik||Medtronic||St. Jude Medical||
  • BackgroundThere are limited data comparing radiofrequency catheter ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation.MethodsWe randomly assigned 294 patients with paroxysmal atrial fibrillation and no history of antiarrhythmic drug use to an initial treatment strategy of either radiofrequency catheter ablation (146 patients) or therapy with class IC or class III antiarrhythmic agents (148 patients). Follow-up included 7-day Holter-monitor recording at 3, 6, 12, 18, and 24 months. Primary end points were the cumulative and per-visit burden of atrial fibrillation (i.e., percentage of time in atrial fibrillation on Holter-monitor recordings). Analyses were performed on an intention-to-treat basis.ResultsThere was no significant difference between the ablation and drug-therapy groups in the cumulative burden of atrial fibrillation (90th percentile of arrhythmia burden, 13% and 19%, respectively; P=0.10) or the burden at 3, 6, 12, or 18 months. At 24 months, the burden of atrial fibrillation was significantly lower in the ablation group than in the drug-therapy group (90th percentile, 9% vs. 18%; P=0.007), and more patients in the ablation group were free from any atrial fibrillation (85% vs. 71%, P=0.004) and from symptomatic atrial fibrillation (93% vs. 84%, P=0.01). One death in the ablation group was due to a procedure-related stroke; there were three cases of cardiac tamponade in the ablation group. In the drug-therapy group, 54 patients (36%) underwent supplementary ablation.ConclusionsIn comparing radiofrequency ablation with antiarrhythmic drug therapy as first-line treatment in patients with paroxysmal atrial fibrillation, we found no significant difference between the treatment groups in the cumulative burden of atrial fibrillation over a period of 2 years.

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  • Johannessen, ArneGentofte University Hospital, Copenhagen, Denmark (author)
  • Raatikainen, PekkaTampere University Hospital, Finland (author)
  • Hindricks, GerhardLeipzig University Hospital, Germany (author)
  • Walfridsson, HåkanÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)hakwa83 (author)
  • Kongstad Rasmussen, OleLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital, Sweden(Swepub:lu)kard-oko (author)
  • Pehrson, SteenRigshospitalet, Copenhagen, Denmark (author)
  • Englund, AndersUniversity Hospital Örebro, Sweden (author)
  • Hartikainen, JuhaKuopio University Hospital, Finland (author)
  • Spange Mortensen, LeifUNI-C, Danish Information Technology Center for Education and Research, Aarhus, Denmark (author)
  • Steen Hansen, PeterAarhus University Hospital, Denmark (author)
  • Aarhus University Hospital, DenmarkGentofte University Hospital, Copenhagen, Denmark (creator_code:org_t)

Related titles

  • In:New England Journal of Medicine: Massachusetts Medical Society367:17, s. 1587-15950028-47931533-4406

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