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  • Abtahi, JahanÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US (author)

Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-12-21
  • Sage Publications,2013
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:liu-89667
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89667URI
  • https://doi.org/10.1177/0022034512472335DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Agholme, FredrikLinköpings universitet,Ortopedi,Hälsouniversitetet(Swepub:liu)freag09 (author)
  • Sandberg, OlofLinköpings universitet,Ortopedi,Hälsouniversitetet(Swepub:liu)olosa45 (author)
  • Aspenberg, PerÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Ortopedkliniken i Linköping(Swepub:liu)peras36 (author)
  • Linköpings universitetOrtopedi (creator_code:org_t)

Related titles

  • In:Journal of Dental Research: Sage Publications92:3, s. 279-2830022-03451544-0591

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