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Downregulation of m...
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Wang, Mo-JinSichuan University, China
(author)
Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-08-11
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Springer Verlag (Germany),2013
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-90208
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90208URI
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https://doi.org/10.1007/s00384-012-1550-3DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|National Natural Science Foundation of China|30830100|Ph.D. Programs Foundation of the Ministry of Education of China|200806100058|
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PurposeRecently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal cancer.MethodsQuantitative real-time PCR was used to analyze miR-124 expression in 96 colorectal cancers and individual-matched normal mucosa samples. The expression of miR-124 was assessed for associations with clinicopathological characteristics using chi-square test. The survival curves were calculated by the Kaplan–Meier method. The influence of each variable on survival was examined by the Cox multivariate regression analysis.ResultsThe miR-124 expression was significantly downregulated in colorectal cancer compared to normal mucosa (P = 0.001). In colorectal cancer, miR-124 decreased expression correlated significantly with the grade of differentiation (P = 0.021). Univariate survival analysis showed that the downregulated miR-124 was significantly correlated with worse prognosis, both in terms of overall survival (P = 0.017) and disease-free survival (DFS) (P = 0.014). Further, the downregulated miR-124 was demonstrated as a prognostic factor for overall survival (hazard ratio, HR = 4.634; 95 % confidence interval, CI, 1.731–12.404; P = 0.002) and DFS (HR = 4.533, 95 % CI 1.733–11.856, P = 0.002), independently of gender, age, location, maximum tumor size, depth of invasion, differentiation, and TNM stage.ConclusionsMiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer.
Subject headings and genre
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MicroRNA-124
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Colorectal cancer
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Quantitative real-time PCR
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Survival
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Li, YuanSichuan University, China
(author)
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Wang, RuiSichuan University, China
(author)
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Wang, CunSichuan University, China
(author)
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Yu, Yong-YangSichuan University, China
(author)
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Yang, LieSichuan University, China
(author)
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Zhang, YiSichuan University, China
(author)
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Zhou, BinSichuan University, China
(author)
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Zhou, Zong-GuangSichuan University, China
(author)
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Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(author)
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Sichuan University, ChinaOnkologi
(creator_code:org_t)
Related titles
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In:International Journal of Colorectal Disease: Springer Verlag (Germany)28:2, s. 183-1890179-19581432-1262
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Wang, Mo-Jin
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Li, Yuan
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Wang, Rui
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Wang, Cun
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Yu, Yong-Yang
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Yang, Lie
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Zhang, Yi
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Zhou, Bin
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Sun, Xiao-Feng
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Linköping University