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  • Andersson, CLund University, Sweden,Barnendokrinologisk forskning/Gustafsson (author)

Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2012-09-10
  • Wiley-Blackwell,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-90675
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-90675URI
  • https://doi.org/10.1111/j.1399-5448.2012.00916.xDOI
  • https://lup.lub.lu.se/record/3124179URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-222288URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:126294072URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council|14064|Swedish Child Diabetes Foundation||Swedish Diabetes Association||National Institutes of Health|DK26190|UMAS Fund||Knut and Alice Wallenberg Foundation||Skane County Council for Research and Development||
  • Co-author: Ingemar Swenne, Uppsala universitet, institutionen för kvinnors och barns hälsa, forskargrupp Barnendokrinologisk forskning, ingår i members of the BDD Study group.
  • Andersson C, Vaziri-Sani F, Delli AJ, Lindblad B, Carlsson A, Forsander G, Ludvigsson J, Marcus C, Samuelsson U, Ivarsson SA, Lernmark A, Elding Larsson H, the BDD Study group. Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatric Diabetes 2013: 14: 97-105. Objective To establish the diagnostic sensitivity of and the relationships between autoantibodies to all three Zinc transporter 8 (Zinc transporter 8 autoantibody to either one, two, or all three amino acid variants at position 325, ZnT8A) variants to human leukocyte antigen (HLA)-DQ and to autoantibodies to glutamic acid decarboxylase (GADA), insulinoma-associated protein 2 (IA-2A), and insulin (IAA). Methods We analyzed 3165 patients with type 1 diabetes (T1D) in the Better Diabetes Diagnosis study for HLA-DQ genotypes and all six autoantibodies (ZnT8RA, arginine 325 Zinc transporter 8 autoantibody; ZnT8WA, tryptophan 325 Zinc transporter 8 autoantibody; ZnT8QA, glutamine 325 Zinc transporter 8 autoantibody; GADA, IA-2A, and IAA). Results ZnT8A was found in 65% of the patients and as many as 108 of 3165 (3.4%) had 13 ZnT8A alone. None had ZnT8QA alone. Together with GADA (56%), IA-2A (73%), and IAA (33%), 93% of the T1D patients were autoantibody positive. All three ZnT8A were less frequent in children below 2 yr of age (pandlt;0.0001). All three ZnT8A were associated with DQA1-B1*X-0604 (DQ6.4) and DQA1-B1*03-0302 (DQ8). ZnT8WA and ZnT8QA were negatively associated with DQA1-B1*05-02 (DQ2). Conclusions Analysis of ZnT8A increased the diagnostic sensitivity of islet autoantibodies for T1D as only 7% remained islet autoantibody negative. The association between DQ6.4 and all three ZnT8A may be related to ZnT8 antigen presentation by the DQ6.4 heterodimer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vaziri Sani, FaribaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden(Swepub:lu)fa3255va (author)
  • Delli, A J.Lund University, Sweden (author)
  • Lindblad, BQueen Silvia Childrens Hospital, Sweden,Queen Silvia Children’s Hospital (author)
  • Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)med-acs (author)
  • Forsander, GQueen Silvia Childrens Hospital, Sweden (author)
  • Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (author)
  • Marcus, CKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Samuelsson, UlfÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping,Linköping University Hospital(Swepub:liu)ulfsa43 (author)
  • Ivarsson, S A.Lund University, Sweden (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden(Swepub:lu)endo-ale (author)
  • Elding Larsson, HLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden(Swepub:lu)pedi-hla (author)
  • Swenne, IngemarUppsala universitet,Pediatrik(Swepub:uu)ingeswen (contributor)
  • Lund University, SwedenBarnendokrinologisk forskning/Gustafsson (creator_code:org_t)
  • The BDD Study Group

Related titles

  • In:Pediatric Diabetes: Wiley-Blackwell14:2, s. 97-1051399-543X1399-5448

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