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The IL12B gene does...
The IL12B gene does not confer susceptibility to coeliac disease.
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Louka, A S (author)
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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D'Alfonso, S (author)
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- Ascher, Henry, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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Coto, I (author)
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Ek, J (author)
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Giordano, M (author)
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- Gudjonsdottir, Audur, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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Mellai, M (author)
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Momigliano-Richiardi, P (author)
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Percopo, S (author)
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- Samuelsson, L (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Wahlström, Jan, 1939 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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Greco, L (author)
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Sollid, L M (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Tissue antigens. - 0001-2815. ; 59:1, s. 70-2
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- Coeliac disease (CD) is a chronic inflammatory disorder where dietary gluten is not tolerated. In the lesion there are gluten reactive T cells predominantly secreting gamma-interferon. Both HLA and non-HLA genes contribute to CD susceptibility. Interleukin-12 (IL-12) regulates gamma-interferon production. The IL12B gene is located in a region (5q31.1-33.1) where there is evidence for linkage with CD. Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D). We found no evidence for association of allele 1 to CD by the transmission/disequilibrium test or case-control approach. No increased frequency was observed in patients belonging to families where the disease was linked to markers on chromosome 5q. Unlike T1D, allele 1 does not appear to confer susceptibility to CD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Alleles
- Celiac Disease
- genetics
- pathology
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- genetics
- Humans
- Interleukin-12
- genetics
- Interleukin-12 Subunit p40
- Intestines
- pathology
- Italy
- Polymorphism
- Genetic
- Scandinavia
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Louka, A S
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Torinsson Naluai ...
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D'Alfonso, S
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Ascher, Henry, 1 ...
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Coto, I
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Ek, J
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show more...
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Giordano, M
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Gudjonsdottir, A ...
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Mellai, M
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Momigliano-Richi ...
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Percopo, S
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Samuelsson, L
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Wahlström, Jan, ...
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Greco, L
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Sollid, L M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Tissue antigens
- By the university
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University of Gothenburg