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Prevalence of Child...
Prevalence of Childhood Celiac Disease and Changes in Infant Feeding
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- Ivarsson, Anneli (author)
- Lund University,Lunds universitet,Umeå universitet,Epidemiologi och global hälsa,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Umeå University, Sweden,Lund University, Sweden
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- Myléus, Anna (author)
- Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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- Norström, Fredrik (author)
- Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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- van der Pals, Maria (author)
- Lund University, Sweden
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- Rosén, Anna (author)
- Umeå universitet,Epidemiologi och global hälsa,Medicinsk och klinisk genetik,Umeå University, Sweden
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- Högberg, Lotta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
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- Danielsson, Lars (author)
- Norrtalje Hospital, Sweden
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- Halvarsson, Britta (author)
- Aleris Medilab, Sweden
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- Hammarroth, Solveig (author)
- Norrtalje Hospital, Sweden
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- Hernell, Olle (author)
- Umeå universitet,Pediatrik,Umeå University, Sweden
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- Karlsson, Eva (author)
- Vaxjo Hospital, Sweden
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- Stenhammar, Lars (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Norrköping
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- Webb, Charlotta (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Sandström, Olof (author)
- Umeå universitet,Pediatrik,Umeå University, Sweden
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- Carlsson, Annelie (author)
- Lund University, Sweden
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- vanderPals, Maria (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2013-03-01
- 2013
- English.
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In: Pediatrics. - : American Academy of Pediatrics. - 0031-4005 .- 1098-4275. ; 131:3, s. E687-E694
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- OBJECTIVES: Between 1984 and 1996, Sweden experienced an "epidemic" of clinical celiac disease in children andlt;2 years of age, attributed partly to changes in infant feeding. Whether infant feeding affects disease occurrence and/or the clinical presentation remains unknown. We investigated and compared the total prevalence of celiac disease in 2 birth cohorts of 12-year-olds and related the findings to each cohorts ascertained infant feeding. less thanbrgreater than less thanbrgreater thanMETHODS: A 2-phase cross-sectional screening study was performed in which 13 279 children from 2 birth cohorts participated: children born during the epidemic (1993) and children born after the epidemic (1997). Previously diagnosed cases were reported and confirmed. Blood samples were analyzed for serological markers and children with positive values were referred for small intestinal biopsy. Infant feeding practices in the cohorts were ascertained via questionnaires. Prevalence comparisons were expressed as prevalence ratios. less thanbrgreater than less thanbrgreater thanRESULTS: The total prevalence of celiac disease was 29 in 1000 and 22 in 1000 for the 1993 and 1997 cohorts, respectively. Children born in 1997 had a significantly lower risk of having celiac disease compared with those born in 1993 (prevalence ratio: 0.75; 95% confidence interval: 0.60-0.93; P = .01). The cohorts differed in infant feeding (specifically, in the proportion of infants introduced to dietary gluten in small amounts during ongoing breastfeeding). less thanbrgreater than less thanbrgreater thanCONCLUSIONS: A significantly reduced prevalence of celiac disease in 12-year-olds indicates an option for disease prevention. Our findings suggest that the present infant feeding recommendation to gradually introduce gluten-containing foods from 4 months of age, preferably during ongoing breastfeeding, is favorable. Pediatrics 2013;131:e687-e694
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- celiac disease
- prevalence
- infant feeding
- MEDICINE
- MEDICIN
- celiac disease
- prevalence
- infant feeding
Publication and Content Type
- ref (subject category)
- art (subject category)
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Pediatrics
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To the university's database
- By the author/editor
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Ivarsson, Anneli
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Myléus, Anna
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Norström, Fredri ...
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van der Pals, Ma ...
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Rosén, Anna
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Högberg, Lotta
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show more...
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Danielsson, Lars
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Halvarsson, Brit ...
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Hammarroth, Solv ...
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Hernell, Olle
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Karlsson, Eva
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Stenhammar, Lars
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Webb, Charlotta
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Sandström, Olof
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Carlsson, Anneli ...
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vanderPals, Mari ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatrics
- By the university
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Linköping University
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Umeå University
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Lund University