Exposure of rabbits to methylchloroform. Vestibulardisturbances correlated to blood and cerebrospinal fluid levels

Larsby, BirgittaLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden (författare)

A previously described experimental model for studying the effects on the central nervous system of rabbits, specifically the vestibular apparatus, has been applied to methylchloroform. To achieve a steady concentration the solvent was infused as a lipid emulsion. The blood and cerebrospinal fluid kinetics have been studied. The arterial blood level seems to be closely correlated to the concentration in the central nervous tissue. Vestibular function has been studied by recording the involuntary eye movements — nystagmus — which are elicited via central vestibulo-oculomotor connections. At blood levels of methylchloroform above 75 ppm a so called “positional nystagmus”, indicated vestibular disturbances, is demonstrated. The relationship between the present findings in rabbits and the reaction and blood concentrations in people exposed to industrial solvents, are discussed.

Tham, RichardLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden(Swepub:liu)ricth61 (författare)
Ödkvist, LarsLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden(Swepub:liu)larod63 (författare)
Norlander, BjörnLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden(Swepub:liu)bjono06 (författare)
Hydén, DagLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden(Swepub:liu)daghy71 (författare)
Aschan, GunnarLinköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden (författare)
Rubin, A.Linköpings universitet,Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden (författare)
Linköpings universitetDepartment of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden (creator_code:org_t)

Ingår i:International Archives of Occupational and Environmental Health: Springer41:1, s. 7-150340-01311432-1246

Av författaren/redakt...: Larsby, Birgitta; Tham, Richard; Ödkvist, Lars; Norlander, Björn; Hydén, Dag; Aschan, Gunnar; visa fler...; Rubin, A.; visa färre...

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