WFRF:(Dahl Jensen Lasse)
Search: WFRF:(Dahl Jensen Lasse) > Clock controls angi...
- 8 of 16
- Previous record
- Next record
- To hitlist
- Jensen, Lasse DahlKarolinska Institutet,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Karolinska Institute, Stockholm, Sweden (author)
Clock controls angiogenesis
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2014-10-28
- Landes Bioscience,2013
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-92648
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-92648URI
- https://doi.org/10.4161/cc.23596DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:126113867URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Circadian rhythms control multiple physiological and pathological processes, including embryonic development in mammals and development of various human diseases. We have recently, in a developing zebrafish embryonic model, discovered that the circadian oscillation controls developmental angiogenesis. Disruption of crucial circadian regulatory genes, including Bmal1 and Period2, results in marked impairment or enhancement of vascular development in zebrafish. At the molecular level, we show that the circadian regulator Bmal1 directly targets the promoter region of the vegf gene in zebrafish, leading to an elevated expression of VEGF. These findings can reasonably be extended to developmental angiogenesis in mammals and even pathological angiogenesis in humans. Thus, our findings, for the first time, shed new light on mechanisms that underlie circadian clock-regulated angiogenesis.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Bmal1
- Clock
- Period2
- VEGF
- angiogenesis
- circadian
- development
- vasculature
- vasculogenesis
- zebrafish
Added entries (persons, corporate bodies, meetings, titles ...)
- Cao, YihaiKarolinska Institutet,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Karolinska Institute, Stockholm, Sweden (author)
- Linköpings universitetAvdelningen för kardiovaskulär medicin (creator_code:org_t)
Related titles
- In:Cell Cycle: Landes Bioscience12:3, s. 405-4081538-41011551-4005
Internet link
- 8 of 16
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jensen, Lasse Da ...
- Cao, Yihai
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Physiology
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Cell Cycle
- By the university
- Linköping University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
