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Overall survival benefit for sequential doxorubicin-docetaxel compared with concurrent doxorubicin and docetaxel in node-positive breast cancer-8-year results of the Breast International Group 02-98 phase III trial
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- Oakman, C (author)
- Hospital Prato, Italy
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- Francis, P A. (author)
- Peter MacCallum Cancer Centre, Australia
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- Crown, J (author)
- Irish Clin Oncology Research Grp, Ireland
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- Quinaux, E (author)
- Int Institute Drug Dev, Belgium
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- Buyse, M (author)
- Int Institute Drug Dev, Belgium
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- De Azambuja, E (author)
- University of Libre Brussels, Belgium
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- Margeli Vila, M (author)
- Hospital Badalona Germans Trias and Pujol, Spain
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- Andersson, M (author)
- Danish Breast Cancer Cooperat Grp, Denmark
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- Nordenskjöld, Bo (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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- Jakesz, R (author)
- Vienna Medical Sch, Austria
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- Thuerlimann, B (author)
- Kantonsspital, Switzerland
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- Gutierrez, J (author)
- Clin Las Condes, Chile
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- Harvey, V (author)
- Auckland City Hospital, New Zealand
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- Punzalan, L (author)
- University of Libre Brussels, Belgium
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- DellOrto, P (author)
- University of Milan, Italy
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- Larsimont, D (author)
- University of Libre Brussels, Belgium
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- Steinberg, I (author)
- Sanofi Oncol, England
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- Gelber, R D. (author)
- IBCSG, MA USA
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- Piccart-Gebhart, M (author)
- University of Libre Brussels, Belgium
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- Viale, G (author)
- University of Milan, Italy
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- Di Leo, A (author)
- Hospital Prato, Italy
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(creator_code:org_t)
- Oxford University Press (OUP): Policy A1, 2013
- 2013
- English.
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In: Annals of Oncology. - : Oxford University Press (OUP): Policy A1. - 0923-7534 .- 1569-8041. ; 24:5, s. 1203-1211
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: In women with node-positive breast cancer, the Breast International Group (BIG) 02-98 tested the incorporation of docetaxel (Taxotere) into doxorubicin (Adriamycin)-based chemotherapy, and compared sequential and concurrent docetaxel. At 5 years, there was a trend for improved disease-free survival (DFS) with docetaxel. We present results at 8-year median follow-up and exploratory analyses within biologically defined subtypes. less thanbrgreater than less thanbrgreater thanMethods: Patients were randomly assigned to one of four treatments: (i) sequential control: doxorubicin (A) (75 mg/m(2)) x 4 -andgt; classical cyclophosphamide, methotrexate, 5-fluorouracil (CMF); (ii) concurrent control: doxorubicin, cyclophosphamide (AC)(60/600 mg/m(2)) x 4 -andgt; CMF; (iii) sequential docetaxel: A (75 mg/m(2)) x3 -andgt; docetaxel (T) (100 mg/m(2)) x3. CMF and (iv) concurrent docetaxel: AT(50/75 mg/m(2)) x 4 -andgt; CMF. The primary comparison evaluated docetaxel efficacy regardless of the schedule. Exploratory analyses were undertaken within biologically defined subtypes. less thanbrgreater than less thanbrgreater thanResults: Two thousand eight hundred and eighty-seven patients were enrolled. After 93.4 months of median follow-up, there were 916 DFS events. For the primary comparison, there was no significant improvement in DFS from docetaxel [hazard ratio (HR) = 0.91, 95% confidence interval (CI) = 0.80-1.05, P = 0.187]. In secondary comparisons, sequential docetaxel significantly improved DFS compared with sequential control (HR = 0.81, 95% CI = 0.67-0.99, P = 0.036), and significantly improved DFS (HR = 0.84, 95% CI = 0.72-0.99, P = 0.035) and overall survival (OS) (HR = 0.79, 95% CI = 0.65-0.98, P = 0.028) compared with concurrent doxorubicin-docetaxel. Luminal-A disease had the best prognosis. HRs favored addition of sequential docetaxel in all subtypes, except luminal-A; but this observation was not statistically supported because of limited numbers. less thanbrgreater than less thanbrgreater thanConclusion: With further follow-up, the sequential docetaxel schedule resulted in significantly better OS than concurrent doxorubicin-docetaxel, and continued to show better DFS than sequential doxorubicin-based control.
Keyword
- adjuvant
- breast cancer
- chemotherapy
- docetaxel
- doxorubicin
- sequential
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Oakman, C
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Francis, P A.
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Crown, J
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Quinaux, E
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Buyse, M
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De Azambuja, E
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show more...
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Margeli Vila, M
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Andersson, M
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Nordenskjöld, Bo
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Jakesz, R
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Thuerlimann, B
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Gutierrez, J
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Harvey, V
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Punzalan, L
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DellOrto, P
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Larsimont, D
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Steinberg, I
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Gelber, R D.
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Piccart-Gebhart, ...
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Viale, G
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Di Leo, A
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- Articles in the publication
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Annals of Oncolo ...
- By the university
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Linköping University