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  • Hansson, Caroline,1981Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg, Sweden (author)

A possible association between panic disorder and a polymorphism in the preproghrelin gene

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Elsevier,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-93863
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93863URI
  • https://doi.org/10.1016/j.psychres.2012.09.051DOI
  • https://research.chalmers.se/publication/178125URI
  • https://gup.ub.gu.se/publication/178125URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:126695790URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Research Council for Medicine|2009-S266|European Commission|FP7-HEALTH-2009-241592FP7-KBBE-2009-3-245009FP7-KBBE-2010-4-266408|FOU/ALF Goteborg|ALFGBG-138741|Swedish Foundation for Strategic Research|A305-188|
  • The aim of the study was to investigate whether polymorphisms in the preproghrelin gene are associated with anxiety disorders, such as panic disorder, in humans. Panic disorder is a severe anxiety disorder, characterized by sudden attacks of intense fear or anxiety in combination with somatic symptoms. The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin. In the present study, we genotyped three missense mutations in the preproghrelin gene in 215 patients suffering from panic disorder and in 451 controls. The A allele of the rs4684677 polymorphism was significantly associated with panic disorder, while there were no significant associations with the two other polymorphisms studied. We conclude that the rs4684677 (Gln90Leu) polymorphism in the preproghrelin gene may be associated with increased risk of panic disorder. It will be important to confirm these findings in additional panic disorder patient groups.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Annerbrink, Kristina,1974Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg, Sweden(Swepub:gu)xannkr (author)
  • Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden(Swepub:gu)xnista (author)
  • Bah, Jessica,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg, Sweden(Swepub:gu)xbahje (author)
  • Olsson, Marie,1971Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg, Sweden(Swepub:gu)xomarz (author)
  • Allgulander, ChristerKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Andersch, Sven,1939Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Sweden(Swepub:gu)xasvem (author)
  • Sjödin, IngemarÖstergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken,Linköping University(Swepub:liu)ingsj97 (author)
  • Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,University of Gothenburg, Sweden(Swepub:gu)xereli (author)
  • Dickson, Suzanne L.,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology,University of Gothenburg, Sweden(Swepub:gu)xdicsu (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi (creator_code:org_t)

Related titles

  • In:Psychiatry Research: Elsevier206:1, s. 22-250165-17811872-7123

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