SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Gregersen Niels)
 

Search: WFRF:(Gregersen Niels) > Bortezomib consolid...

  • Mellqvist, Ulf-HenrikSahlgrens University Hospital, Sweden (author)

Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • American Society of Hematology,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-96994
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96994URI
  • https://doi.org/10.1182/blood-2012-11-464503DOI
  • https://lup.lub.lu.se/record/4043201URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223033URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127146949URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79913URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Johnson Johnson||Nordic Cancer Union||Boras foundation for cancer research||
  • The Nordic Myeloma Study Group conducted an open randomized trial to compare bortezomib as consolidation therapy given after high-dose therapy and autologous stem cell transplantation (ASCT) with no consolidation in bortezomib-naive patients with newly diagnosed multiple myeloma. Overall, 370 patients were centrally randomly assigned 3 months after ASCT to receive 20 doses of bortezomib given during 21 weeks or no consolidation. The hypothesis was that consolidation therapy would prolong progression-free survival (PFS). The PFS after randomization was 27 months for the bortezomib group compared with 20 months for the control group (P = .05). Fifty-one of 90 patients in the treatment group compared with 32 of 90 controls improved their response after randomization (P = .007). No difference in overall survival was seen. Fatigue was reported more commonly by the bortezomib-treated patients in self-reported quality-of-life (QOL) questionnaires, whereas no other major differences in QOL were recorded between the groups. Consolidation therapy seemed to be beneficial for patients not achieving at least a very good partial response (VGPR) but not for patients in the andgt;= VGPR category at randomization. Consolidation with bortezomib after ASCT in bortezomib-naive patients improves PFS without interfering with QOL. This trial was registered at www.clinicaltrials.gov as #NCT00417911.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gimsing, PeterRigshosp, Denmark (author)
  • Hjertner, OyvindNorwegian University of Science and Technology, Norway (author)
  • Lenhoff, StigLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)med-slf (author)
  • Laane, EdwardNorth Estonian Regional Hospital, Estonia (author)
  • Remes, KariTurku University, Finland (author)
  • Steingrimsdottir, HlifLandspitali University Hospital, Iceland (author)
  • Abildgaard, NielsOdense University Hospital, Denmark (author)
  • Ahlberg, LuciaÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US(Swepub:liu)lucah64 (author)
  • Blimark, CecilieSahlgrens University Hospital, Sweden (author)
  • Dahl, Inger MarieUniversity of North Norway, Norway (author)
  • Forsberg, KarinUmeå universitet,Patologi,Norrlands University Hospital, Sweden(Swepub:umu)nonkin02 (author)
  • Gedde-Dahl, TobiasOslo University Hospital, Norway (author)
  • Gregersen, HenrikAalborg Hospital, Denmark (author)
  • Gruber, AstridKarolinska Institute, Sweden (author)
  • Guldbrandsen, NinaOslo University Hospital, Norway (author)
  • Haukas, EinarStavanger University Hospital, Norway (author)
  • Carlson, KristinaUppsala universitet,Hematologi,Akad University Hospital, Sweden(Swepub:uu)krica965 (author)
  • Kvam, Ann KristinOslo University Hospital, Norway (author)
  • Nahi, HarethKarolinska Institutet,Karolinska Institute, Sweden (author)
  • Lindas, RoaldHaukeland Hospital, Norway (author)
  • Frost Andersen, NielsAarhus University Hospital, Denmark (author)
  • Turesson, IngemarLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden(Swepub:lu)medf-itu (author)
  • Waage, AndersNorwegian University of Science and Technology, Norway (author)
  • Westin, JanSahlgrens University Hospital, Sweden (author)
  • Sahlgrens University Hospital, SwedenRigshosp, Denmark (creator_code:org_t)

Related titles

  • In:Blood: American Society of Hematology121:23, s. 4647-46540006-49711528-0020

Internet link

Find in a library

  • Blood (Search for host publication in LIBRIS)

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view