WFRF:(Ortqvist Eva)
Sökning: WFRF:(Ortqvist Eva) > (2010-2014) > A multicenter obser...
- Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden (författare)
A multicenter observational safety study in Swedish children and adolescents using insulin detemir for the treatment of type 1 diabetes
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- 2013-03
- Wiley-Blackwell,2013
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-97244
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97244URI
- https://doi.org/10.1111/pedi.12019DOI
- https://lup.lub.lu.se/record/3628747URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:127217209URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Funding Agencies|Novo Nordisk Scandinavia AB||
- This 26-wk observational study in children and adolescents with type 1 diabetes (T1D) in Sweden investigated the safety and efficacy of insulin detemir (IDet) in newly diagnosed (ND) patients and those with established diabetes (ED) switching to IDet. A total of 159 patients initiated IDet as part of basal-bolus therapy, 59 in the ND stratum (mean age 9.7yr) and 97 in the ED stratum (mean age 12.5 yr). The primary outcome measure was the incidence of severe adverse drug reactions; just one major hypoglycemic event occurred in a patient in the ND stratum during the study and one patient was withdrawn due to injection-site reactions. All other events were classified as mild. In the ED stratum, there was a reduction in hypoglycemic events in the 4wk prior to study end from baseline (mean reduction of 2.46 events, not significant) and a significant reduction in nocturnal hypoglycemia (mean reduction of 2.24 events, p=0.0078). Glycemic control improved in the ND stratum as expected and, in the ED stratum, there was no significant change in HbA1c from baseline (mean reduction of -0.45%). At study end, mean daily IDet doses were 0.39U/kg (ND) and 0.54U/kg (ED). Weight increased by 5.7 and 2.0kg in the ND and ED strata, respectively, and was within the normal limits for growing children. IDet provided good glycemic control and was well tolerated, with a reduced risk of nocturnal hypoglycemia in a heterogeneous cohort of children and adolescents with T1D.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
- detemir
- pediatrics
- safety
- type 1 diabetes
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Forsander, GunSahlgrens University Hospital, Sweden (författare)
- Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29 (författare)
- Larsen, SaraNovo Nordisk Scandinavia AB, Sweden (författare)
- Ortqvist, EvaKarolinska Institutet,Karolinska University Hospital, Sweden (författare)
- Pediatrik, LundSektion V (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Pediatric Diabetes: Wiley-Blackwell14:5, s. 358-3651399-543X1399-5448
Internetlänk
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.12019
- http://www.ncbi.nlm.nih.gov/pubmed/23448369?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1111/pedi.12019FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-97244
- https://doi.org/10.1111/pedi.12019
- https://lup.lub.lu.se/record/3628747
- http://kipublications.ki.se/Default.aspx?queryparsed=id:127217209
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- Larsen, Sara
- Ortqvist, Eva
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
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