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Genes identified in...
Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
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- Wang, Chuan (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Ahlford, Annika (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Jarvinen, Tiina M. (author)
- University of Helsinki, Finland
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi
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- Eloranta, Maija-Leena (author)
- Uppsala universitet,Reumatologi
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- Gunnarsson, Iva (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Padyukov, Leonid (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Truedsson, Lennart (author)
- Lund University, Sweden
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- Eriksson, Catharina (author)
- Umeå universitet,Klinisk immunologi,University of Umeå Hospital, Sweden
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- Rantapää-Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi,Umeå University, Sweden
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- Sjöwall, Christoffer (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Julkunen, Heikki (author)
- Peijas Hospital, Finland
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- Criswell, Lindsey A. (author)
- University of Calif San Francisco, CA USA
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- Graham, Robert R. (author)
- Genentech Inc, CA USA
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- Behrens, Timothy W. (author)
- Genentech Inc, CA USA
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- Kere, Juha (author)
- Karolinska Institutet,University of Helsinki, Finland
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- Rönnblom, Lars (author)
- Uppsala universitet,Reumatologi
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Sandling, Johanna K (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2012-12-19
- 2013
- English.
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In: European Journal of Human Genetics. - : Nature Publishing Group: Open Access Hybrid Model Option B. - 1018-4813 .- 1476-5438. ; 21:9, s. 994-999
- Related links:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case–control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- systemic lupus erythematosus
- genetic-association study
- Asian
- Caucasian
- MEDICINE
- MEDICIN
- systemic lupus erythematosus
- genetic-association study
- Asian
- Caucasian
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Chuan
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Ahlford, Annika
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Jarvinen, Tiina ...
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Nordmark, Gunnel
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Eloranta, Maija- ...
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Gunnarsson, Iva
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Svenungsson, Eli ...
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Padyukov, Leonid
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Sturfelt, Gunnar
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Jönsen, Andreas
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Bengtsson, Ander ...
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Truedsson, Lenna ...
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Eriksson, Cathar ...
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Rantapää-Dahlqvi ...
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Sjöwall, Christo ...
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Julkunen, Heikki
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Criswell, Lindse ...
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Graham, Robert R ...
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Behrens, Timothy ...
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Kere, Juha
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Rönnblom, Lars
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Syvänen, Ann-Chr ...
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Sandling, Johann ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Umeå University
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Karolinska Institutet
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Lund University
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Uppsala University