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Tyrosine kinase inh...
Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Sandin, Fredrik (author)
- Regional Cancer Centre, Sweden
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- Hellstrom, Karin (author)
- Regional Cancer Centre, Sweden
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- Bjoreman, Mats (author)
- University Hospital, Sweden
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- Bjorkholm, Magnus (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Brune, Mats (author)
- Sahlgrens University Hospital, Sweden
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- Dreimane, Arta (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Ekblom, Marja (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
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- Lehmann, Soren (author)
- Uppsala universitet,Karolinska Institutet,Hematologi,Karolinska University Hospital, Sweden
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- Ljungman, Per (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Malm, Claes (author)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US
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- Markevärn, Berit (author)
- Umeå universitet,Medicin,Umeå University Hospital, Sweden
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- Myhr-Eriksson, Kristina (author)
- Sunderby Luleå Hospital, Sweden
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- Ohm, Lotta (author)
- Karolinska University Hospital, Sweden
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Själander, Anders (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
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- Wadenvik, Hans (author)
- Sahlgrens University Hospital, Sweden
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- Simonsson, Bengt (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden
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- Stenke, Leif (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Richter, Johan (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
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(creator_code:org_t)
- American Society of Hematology, 2013
- 2013
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 122:7, s. 1284-1292
- Related links:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95% of all patients diagnosed with chronic myeloid leukemia (CML) are reported to the national CML registry, providing unique possibilities to compile population-based information. This report is based on registry data from 2002 to 2010, when a total of 779 patients (425 men, 354 women; median age, 60 years) were diagnosed with CML (93% chronic, 5% accelerated, and 2% blastic phase) corresponding to an annual incidence of 0.9/100 000. In 2002, approximately half of the patients received a tyrosine kinase inhibitor as initial therapy, a proportion that increased to 94% for younger (andlt;70 years) and 79% for older (andgt;80 years) patients during 2007-2009. With a median follow-up of 61 months, the relative survival at 5 years was close to 1.0 for patients younger than 60 years and 0.9 for those aged 60 to 80 years, but only 0.6 for those older than 80 years. At 12 months, 3% had progressed to accelerated or blastic phase. Sokal, but not European Treatment and Outcome Study, high-risk scores were significantly linked to inferior overall and relative survival. Patients living in university vs nonuniversity catchment areas more often received tyrosine kinase inhibitors up front but showed comparable survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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To the university's database
- By the author/editor
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Höglund, Martin
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Sandin, Fredrik
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Hellstrom, Karin
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Bjoreman, Mats
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Bjorkholm, Magnu ...
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Brune, Mats
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show more...
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Dreimane, Arta
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Ekblom, Marja
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Lehmann, Soren
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Ljungman, Per
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Malm, Claes
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Markevärn, Berit
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Myhr-Eriksson, K ...
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Ohm, Lotta
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Olsson-Strömberg ...
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Själander, Ander ...
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Wadenvik, Hans
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Simonsson, Bengt
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Stenke, Leif
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Richter, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Linköping University
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Lund University
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Karolinska Institutet
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Uppsala University
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Umeå University