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Nod1, Nod2 and Nalp...
Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?
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- Bogefors, J. (author)
- Department of Otorhinolaryngology, Malmö University Hospital, Lund University, Malmö, Sweden
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- Rydberg, C. (author)
- Karolinska Institutet
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- Uddman, Rolf (author)
- Lund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Department of Otorhinolaryngology, Malmö University Hospital, Lund University, Malmö, Sweden
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- Fransson, Mattias (author)
- Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Department of Otorhinolaryngology, Malmö University Hospital, Lund University, Malmö, Sweden
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- Månsson, Anne (author)
- Lund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Division of ENT diseases, CLINTEC, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Benson, Mikael (author)
- Unit for Clinical Systems Biology, Department of Pediatrics, Queen Silvia Children’s Hospital, Gothenburg, Sweden
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- Adner, M. (author)
- Karolinska Institutet
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- Cardell, Lars-Olaf (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk och experimentell allergiforskning,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Clinical and Experimental Allergy Research,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Division of ENT diseases, CLINTEC, Huddinge, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2010-04-07
- 2010
- English.
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley-Blackwell. - 0105-4538 .- 1398-9995. ; 65:10, s. 1222-1226
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- BACKGROUND: Recently, a new set of pattern-recognition receptors, the nucleotide-binding oligomerization domain (Nod)-like receptors (NLRs), have emerged. Their activation, either by allergens or microbes, triggers an inflammatory response. The knowledge about NLRs in human airways is limited.AIM OF THE STUDY: To investigate presence of NLRs in the human nose of healthy individuals and patients with intermittent allergic rhinitis outside and during pollen season.METHODS: The expression of Nod1, Nod2, and Nalp3 in nasal biopsies was determined with real-time RT-PCR and immunohistochemistry. Cultured primary human nasal epithelial cells (HNECs) were analyzed using real-time RT-PCR and flow cytometry to further verify the presence of NLRs in the epithelium.RESULTS: Immunohistochemical analysis revealed presence of Nod1, Nod2, and Nalp3 in the nasal epithelium. This was corroborated in cultured HNECs. Patients suffering from symptomatic allergic rhinitis exhibited lower Nod1 and Nalp3 mRNA levels than both controls and patients during pollen season. Nod2 expression was found in all specimens tested, but no differences were seen between the three groups.CONCLUSION: Nod1, Nod2, and Nalp3 receptors were found to be present in the human nose. The expression of Nod1 and Nalp3 were down-regulated during pollen season among patients with allergic rhinitis. This opens up for new insights and novel therapeutic strategies in inflammatory airway disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- intermittent allergic rhinitis; Nalp3; NLRs; Nod1; Nod2
Publication and Content Type
- ref (subject category)
- art (subject category)
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