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ERdj5, an endoplasm...
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
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- Cunnea, Paula M (author)
- Centre for Biotechnology, Department of Biosciences at Novum, Karolinska Institute, Södertörns Högskola, S-14157 Huddinge, Sweden.
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- Miranda-Vizuete, Antonio (author)
- Centre for Biotechnology, Department of Biosciences at Novum, Karolinska Institute, Södertörns Högskola, S-14157 Huddinge, Sweden.
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- Bertoli, Gloria (author)
- Università Vita-Salute San Raffaele, 20132 Milan, Italy
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- Simmen, Thomas (author)
- Università Vita-Salute San Raffaele, 20132 Milan, Italy
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- Damdimopoulos, Anastasios E (author)
- Karolinska Institutet
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- Hermann, Stefan (author)
- Södertörns högskola,Avdelning Naturvetenskap,Centre for Biotechnology, Department of Biosciences at Novum, Karolinska Institute, Södertörns Högskola, S-14157 Huddinge, Sweden.
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- Leinonen, Saku (author)
- Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institutet, SE-141 57 Huddinge, Sweden
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- Huikko, Markku Pelto (author)
- Department of Pathology, Tampere University Hospital, Fin-33101 Tampere, Finland
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- Gustafsson, Jan-Ake (author)
- Karolinska Institutet
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- Sitia, Roberto (author)
- Department of Biological and Technological Research, San Raffaele Scientific Institute / Università Vita-Salute San Raffaele, 20132 Milan, Italy
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- Spyrou, Giannis (author)
- Centre for Biotechnology, Department of Biosciences at Novum, Karolinska Institute, Södertörns Högskola, S-14157 Huddinge, Sweden.
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Centre for Biotechnology, Department of Biosciences at Novum, Karolinska Institute, Södertörns Högskola, S-14157 Huddinge, Sweden Università Vita-Salute San Raffaele, 20132 Milan, Italy (creator_code:org_t)
- 2003
- 2003
- English.
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In: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 278:2, s. 1059-66
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- A complex array of chaperones and enzymes reside in the endoplasmic reticulum (ER) to assist the folding and assembly of and the disulfide bond formation in nascent secretory proteins. Here we characterize a novel human putative ER co-chaperone (ERdj5) containing domains resembling DnaJ, protein-disulfide isomerase, and thioredoxin domains. Homologs of ERdj5 have been found in Caenorhabditis elegans and Mus musculus. In vitro experiments demonstrated that ERdj5 interacts via its DnaJ domain with BiP in an ATP-dependent manner. ERdj5 is a ubiquitous protein localized in the ER and is particularly abundant in secretory cells. Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cunnea, Paula M
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Miranda-Vizuete, ...
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Bertoli, Gloria
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Simmen, Thomas
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Damdimopoulos, A ...
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Hermann, Stefan
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show more...
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Leinonen, Saku
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Huikko, Markku P ...
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Gustafsson, Jan- ...
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Sitia, Roberto
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Spyrou, Giannis
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Journal of Biolo ...
- By the university
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Linköping University
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Södertörn University
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Karolinska Institutet