onr:"swepub:oai:DiVA.org:liu-99417"
Sökning: onr:"swepub:oai:DiVA.org:liu-99417" > Hypoxia in the diab...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Nordquist, LinaUppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University (författare)
Hypoxia in the diabetic kidney is independent of advanced glycation end-products.
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- 2012-07-21
- New York, NY :Kluwer Academic Publishers,2013
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-99417
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99417URI
- https://doi.org/10.1007/978-1-4614-4989-8_26DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182297URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Sustained hyperglycemia is closely associated with increased risk to develop nephropathy. We have previously reported alterations in the intrarenal oxygen metabolism already after the early onset of diabetes. Furthermore, formation of advanced glycation end-products (AGE) is postulated as a major contributor to diabetic nephropathy. We therefore investigated the possible relationship between altered oxygen metabolism and AGE in diabetic kidneys.Normoglycemic and streptozotocin-diabetic rats with and without chronic treatment with aminoguanidine (AGE inhibitor; 600 mg/kg bw/24 h in drinking water) or L-N(6)-(1-Iminoethyl)lysine (L-NIL, iNOS inhibitor, 1 mg/kg bw/24 h in drinking water) were studied 2 weeks after induction of diabetes. Glomerular filtration rate (GFR) was estimated by inulin clearance, oxygen tension (pO(2)) and interstitial pH by microelectrodes and regional renal blood flow (RBF) by laser-Doppler. Histological changes were evaluated on fixed tissue.Glomerular hyperfiltration was unaffected by aminoguanidine, whereas L-NIL normalized GFR in diabetic rats. pO(2) and interstitial pH, but not RBF, were lower in both kidney cortex and medulla compared to control rats, but was unaffected by both chronic treatments. Urinary protein excretion was higher in diabetic rats and unaffected by L-NIL, whereas aminoguanidine paradoxically increased this parameter. Damage scores were similar in all groups.In conclusion, diabetes-induced alterations in intrarenal oxygen metabolism are independent of the AGE pathway, and precede any morphological changes. These findings highlight the early stage of diabetes as being a metabolic disorder also in the kidney.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Liss, Per,1960-Uppsala universitet,Enheten för radiologi,Radiology, Oncology and Radiation Science, Uppsala University(Swepub:uu)perliss (författare)
- Fasching, AngelicaUppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University(Swepub:uu)afa22979 (författare)
- Hansell, PeterUppsala universitet,Integrativ Fysiologi,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University(Swepub:uu)petehans (författare)
- Palm, Fredrik,1973-Uppsala universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet,Division of Integrative Physiology, Departments of Medical Cell Biology, Uppsala University, Biomedical Center,Integrativ Fysiologi(Swepub:uu)fredpalm (författare)
- Uppsala universitetIntegrativ Fysiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Advances in Experimental Medicine and BiologyNew York, NY : Kluwer Academic Publishers765, s. 185-1930065-25982214-8019
Internetlänk
Hitta via bibliotek
- Advances in Experimental Medicine and Biology (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Nordquist, Lina
- Liss, Per, 1960-
- Fasching, Angeli ...
- Hansell, Peter
- Palm, Fredrik, 1 ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Cell och molekyl ...
- Artiklar i publikationen
- Advances in Expe ...
- Av lärosätet
- Linköpings universitet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
