Search: WFRF:(Van Veldhuisen Dirk J.) >
Inflammation and an...
Inflammation and anaemia in a broad spectrum of patients with heart failure
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- Kleijn, Lennaert (author)
- University Medical Center Groningen, Netherlands
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- Belonje, Anne M S (author)
- University Medical Center Groningen, Netherlands
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- Voors, Adriaan A (author)
- University Medical Center Groningen, Netherlands
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- De Boer, Rudolf A (author)
- University Medical Center Groningen, Netherlands
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- Jaarsma, Tiny (author)
- Linköpings universitet,Hälsa, Aktivitet, Vård (HAV),Hälsouniversitetet,University Medical Center Groningen, Netherlands
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- Ghosh, Sudip (author)
- Amgen Ltd, Cambridge, UK
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- Kim, Joseph (author)
- Amgen Ltd, Cambridge, UK
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- Hillege, Hans L (author)
- University Medical Center Groningen, Netherlands
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- Van Gilst, Wiek H (author)
- University Medical Center Groningen, Netherlands
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- van Veldhuisen, Dirk J (author)
- University Medical Center Groningen, Netherlands
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- van der Meer, Peter (author)
- University Medical Center Groningen, Netherlands
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(creator_code:org_t)
- 2012-06-22
- 2012
- English.
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In: Heart. - : BMJ Publishing Group. - 1355-6037 .- 1468-201X. ; 98:16, s. 1237-1241
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AIMS: Anaemia in heart failure (HF) is associated with a poor prognosis. Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established.METHODS: Data from a multicentre randomised clinical trial, in which patients were eligible if they were >18 years of age and admitted for HF (New York Heart Association II-IV), were used. In a subset of 326 patients, haemoglobin (Hb), haematocrit, high sensitivity C-reactive protein (hsCRP), interleukin-(IL) 6, soluble tumour necrosis factor receptor (sTNFR)-1 and erythropoietin (Epo) were measured at discharge and the primary endpoint was all-cause mortality. Follow-up was 18 months.RESULTS: Anaemia (Hb <13 g/dl (men) and <12 g/dl (women)) was present in 40% (130/326) of the study population. Median levels of IL-6, hsCRP and sTNFR-1 were significantly higher in anaemic patients than in non-anaemic patients. Logistic regression demonstrated that each increase in hsCRP values (OR 1.58 per SD log hsCRP; 95% CI 1.09 to 2.29; p=0.016) and each increase in sTNFR-1 values (OR 1.62 per SD log sTNFR-1; 95% CI 1.24 to 2.11; p<0.001) were independently associated with anaemia. Epo (HR 1.31 per log Epo; 95% CI 1.01 to 1.69; p=0.041) and sTNFR-1 (HR 1.47 per log sTNFR-1; 95% CI 1.16 to 1.86; p=0.001) levels were independently associated with outcome.CONCLUSION: Anaemia is present in 40% of patients hospitalised for HF and is independently associated with inflammation.
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Heart
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- By the author/editor
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Kleijn, Lennaert
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Belonje, Anne M ...
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Voors, Adriaan A
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De Boer, Rudolf ...
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Jaarsma, Tiny
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Ghosh, Sudip
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show more...
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Kim, Joseph
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Hillege, Hans L
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Van Gilst, Wiek ...
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van Veldhuisen, ...
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van der Meer, Pe ...
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Heart
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Linköping University