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Further characteriz...
Further characterization of hormonal regulation of glutathione transferase in rat liver and adrenal glands. Sex differences and demonstration that growth hormone regulates the hepatic levels
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- Staffas, Louise (author)
- Wallenberg Laboratory, Stockholm University, Sweden
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- Mankowitz, Louise (author)
- Wallenberg Laboratory, Stockholm University, Sweden
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- Söderström, Mats (author)
- Wallenberg Laboratory, Stockholm University, Sweden
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- Blanck, Agneta (author)
- Huddinge University Hospital, Sweden
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- Porsch-Hällström, Inger (author)
- Huddinge University Hospital, Sweden
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- Sundberg, Carola (author)
- Wallenberg Laboratory, Stockholm University, Sweden
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- Mannervik, Bengt (author)
- Uppsala University, Sweden
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- Olin, Birgit (author)
- Uppsala University, Sweden
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- Rydström, Jan (author)
- Royal Institute of Technology, Stockholm, Sweden
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- DePierre, Joseph W (author)
- Wallenberg Laboratory, Stockholm University, Sweden
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(creator_code:org_t)
- Portland Press, 1992
- 1992
- English.
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In: Biochemical Journal. - : Portland Press. - 0264-6021 .- 1470-8728. ; 286 ( Pt 1), s. 65-72
- Related links:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
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- Immunoblot experiments and reverse-phase h.p.l.c. were used to study the levels of glutathione transferase subunits 1, 2, 3, 4, 6, 7 and 8 in the liver and adrenal of intact and hypophysectomized male and female Sprague-Dawley rats. A sexual dimorphism in the levels of several of these isoenzymes and in their responses to hypophysectomy was demonstrated. In the liver of sham-operated females and males there are differences in glutathione transferase activities and isoenzyme pattern. H.p.l.c. analysis showed higher levels of subunits 1, 3 and 4 in male rats compared with females. In contrast with the pronounced sex differences in sham-operated rats, the isoenzyme patterns of hypophysectomized males and females were very similar. In the adrenal glands, however, a sexual dimorphism became apparent only after hypophysectomy, when the level of subunit 4 was increased 14-fold in the female, whereas the corresponding increase in the male rat was only 2.7-fold. The hepatic pattern of glutathione transferase subunits could be altered by continuous infusion of growth hormone to both sham-operated and hypophysectomized rats of both sexes. This treatment feminized the isoenzyme pattern in sham-operated males and a similar effect was obtained upon treating hypophysectomized rats with thyroxine, cortisone acetate and a continuous infusion of growth hormone.
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