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Sökning: id:"swepub:oai:DiVA.org:liu-99968" > Arteriogenesis: Non...

  • Zhuang, Zhen W.Dartmouth Medical School, Lebanon, NH, USA (författare)

Arteriogenesis: Noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents

  • Artikel/kapitelEngelska2006

Förlag, utgivningsår, omfång ...

  • Radiological Society of North America (RSNA),2006
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-99968
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-99968URI
  • https://doi.org/10.1148/radiol.2403050976DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • PURPOSE:To evaluate two-dimensional (2D) multi-detector row computed tomographic (CT) angiography and three-dimensional (3D) volume rendering for depiction of patterns of arterial growth and quantification of blood vessel density and volume.MATERIALS AND METHODS:The institutional animal care and use committee approved this study. The right femoral artery and its branches were ligated and excised in 16 inbred Lewis rats; animals were randomly assigned to receive 70 microL Dulbecco's modified Eagle's medium (DMEM) or 1.5 x 10(7) bone marrow-derived mononuclear cells (BMC) from isogenic donor rats in 70 microL DMEM. At 2 weeks, CT angiography was performed with injection of 0.45 mL barium sulfate suspension at 0.7 mL/min, followed by silver staining. Number of blood vessels, area, mean area, volume, and blood vessel size distribution derived from digitally subtracted 2D CT angiographic sections were quantified; 3D images were reconstructed. Two-way analysis of variance and paired and unpaired Student t tests were performed.RESULTS:CT angiography showed two patterns of arterial growth: collateral arterial formation and branching arteriogenesis. Two-way analysis of variance indicated that differences within subjects (ischemic vs nonischemic legs) and between subjects (BMC vs DMEM treatment) were significant for total blood vessel area, total blood vessel volume, and mean of blood vessel area (P < .001). In the BMC group, there were significantly more arteries (mean, 241.6 +/- 77.0 [standard deviation] vs 196.4 +/- 75.2, P = .028), but mean cross-sectional area of these arteries was smaller in ischemic versus nonischemic legs (5.4 mm(2) +/- 1.2 vs 6.8 mm(2) +/- 1.3, P = .006). Total arterial area and volume did not differ significantly between ischemic and nonischemic legs.CONCLUSION:BMC injection had a substantial effect on arteriogenesis, with normalization of total arterial area and volume in the BMC group; this effect was successfully depicted.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gao, LingDartmouth Medical School, Lebanon, NH, USA (författare)
  • Murakami, MasahiroDartmouth Medical School, Lebanon, NH, USA (författare)
  • Pearlman, JustinDartmouth Medical School, Lebanon, NH, USA (författare)
  • Sackett, TerryDartmouth Medical School, Lebanon, NH, USA (författare)
  • Simons, MichaelDartmouth Medical School, Lebanon, NH, USA (författare)
  • de Muinck, Ebo D.Dartmouth Medical School, Lebanon, NH, USA(Swepub:liu)ebode21 (författare)
  • Dartmouth Medical School, Lebanon, NH, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Radiology: Radiological Society of North America (RSNA)240:3, s. 698-7070033-84191527-1315

Internetlänk

Hitta via bibliotek

  • Radiology (Sök värdpublikationen i LIBRIS)

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