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Sphenostylisins A-K :
Sphenostylisins A-K : bioactive modified isoflavonoid constituents of the root bark of Sphenostylis marginata ssp. erecta
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- Li, Jie (författare)
- Ohio State University, USA
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- Pan, Li (författare)
- Ohio State University, USA
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- Deng, Ye (författare)
- Ohio State University, USA
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- Acuña, Ulyana Muñoz (författare)
- Ohio State University, USA
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- Yuan, Chunhua (författare)
- Ohio State University, USA
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- Lai, Hongshan (författare)
- Ohio State University, USA
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- Chai, Heebyung (författare)
- Ohio State University, USA
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- Chagwedera, Tangai E (författare)
- University of Zimbabwe, Zimbabwe
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- Farnsworth, Norman R (författare)
- University of Illinois at Chicago, USA
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- Carcache de Blanco, Esperanza J (författare)
- Ohio State University, USA
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- Li, Chenglong (författare)
- Ohio State University, USA
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- Soejarto, Djaja D (författare)
- University of Illinois at Chicago, USA;Field Museum of Natural History, USA
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- Kinghorn, A Douglas (författare)
- Ohio State University, USA
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(creator_code:org_t)
- 2013-10-03
- 2013
- Engelska.
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 78:20, s. 10166-10177
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sphenostylisins A-C (1-3), three complex dimeric compounds representing two novel carbon skeletons, along with an additional eight new compounds, sphenostylisins D-K (4-11), were isolated from the active chloroform-soluble extract of the root bark of Sphenostylis marginata ssp. erecta using a bioactivity-guided isolation approach. The structures were elucidated by means of detailed spectroscopic analysis, including NMR and HRESIMS analysis, and tandem MS fragmentation was utilized to further support the structures of 1-3. The absolute configuration of sphenostylisin C (3) was established by electronic circular dichroism analysis. Plausible biogenetic relationships between the modified isoflavonoids 1-11 are proposed, and a cyclization reaction of 9 was conducted to support one of the biogenetic proposals made. All of these pure isolates were evaluated against a panel of in vitro bioassays, and among the results obtained, sphenostylisin A (1) was found to be a very potent NF-κB inhibitor (IC50 = 6 nM).
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- NF-κB
- drug discovery
- Organic Chemistry
- Organisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Li, Jie
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Pan, Li
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Deng, Ye
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Acuña, Ulyana Mu ...
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Yuan, Chunhua
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Lai, Hongshan
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Chai, Heebyung
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Chagwedera, Tang ...
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Farnsworth, Norm ...
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Carcache de Blan ...
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Li, Chenglong
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Soejarto, Djaja ...
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Kinghorn, A Doug ...
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