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Effect of atorvasta...
Effect of atorvastatin on muscle symptoms in coronary heart disease patients with self-perceived statin muscle side-effects : a randomized, double-blinded crossover trial
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- Kristiansen, Oscar (författare)
- Drammen Hospital, Norway;University of Oslo, Norway
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- Vethe, Nils Tore (författare)
- Oslo University Hospital, Norway
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- Peersen, Kari (författare)
- Vestfold Hospital Trust, Norway
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- Fagerland, Morten Wang (författare)
- Oslo University Hospital, Norway
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- Sverre, Elise (författare)
- Drammen Hospital, Norway;University of Oslo, Norway
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- Jensen, Elena Prunés (författare)
- Vestre Viken Hospital Trust, Norway
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- Lindberg, Morten (författare)
- Vestfold Hospital Trust, Norway
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- Gjertsen, Erik (författare)
- Drammen Hospital, Norway
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- Gullestad, Lars (författare)
- Oslo University Hospital, Norway;University of Oslo, Norway
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- Perk, Joep, 1945- (författare)
- Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap (HV)
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- Dammen, Toril (författare)
- University of Oslo, Norway
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- Bergan, Stein (författare)
- Oslo University Hospital, Norway
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- Husebye, Einar (författare)
- Drammen Hospital, Norway
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- Otterstad, Jan Erik (författare)
- Vestfold Hospital Trust, Norway
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- Munkhaugen, John (författare)
- Drammen Hospital, Norway;University of Oslo, Norway
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(creator_code:org_t)
- 2020-07-01
- 2021
- Engelska.
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Ingår i: European Heart Journal - Cardiovascular Pharmacotherapy. - : Oxford University Press. - 2055-6837 .- 2055-6845. ; 7:6, s. 507-516
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS: To estimate the effect of atorvastatin on muscle symptom intensity in coronary heart disease (CHD) patients with self-perceived statin-associated muscle symptoms (SAMS) and to determine the relationship to blood levels of atorvastatin and/or metabolites.METHODS AND RESULTS: A randomized multi-center trial consecutively identified 982 patients with previous or ongoing atorvastatin treatment after a CHD event. Of these, 97 (9.9%) reported SAMS and 77 were randomized to 7-weeks double-blinded treatment with atorvastatin 40 mg/day and placebo in a crossover design. The primary outcome was the individual mean difference in muscle symptom intensity between the treatment periods, measured by visual-analogue scale (VAS) scores. Atorvastatin did not affect the intensity of muscle symptoms among 71 patients who completed the trial. Mean VAS difference [statin-placebo] was 0.31 (95% CI -0.24-0.86). The proportion with more muscle symptoms during placebo than atorvastatin was 17% (n = 12), 55% (n = 39) had the same muscle symptom intensity during both treatment periods whereas 28% (n = 20) had more symptoms during atorvastatin than placebo (confirmed SAMS). There were no differences in clinical or pharmacogenetic characteristics between these groups. The levels of atorvastatin and/or metabolites did not correlate to muscle symptom intensity among patients with confirmed SAMS (Spearmans rho ≤0.40, for all variables).CONCLUSION: Re-challenge with high-intensity atorvastatin did not affect the intensity of muscle symptoms in CHD patients with self-perceived SAMS during previous atorvastatin therapy. There was no relationship between muscle symptoms and the systemic exposure to atorvastatin and/or its metabolites. The findings encourage an informed discussion to elucidate other causes of muscle complaints and continued statin use.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Statin associated muscle symptoms
- atorvastatin
- coronary heart disease
- cross-over trial
- placebo-controlled
- Medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kristiansen, Osc ...
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Vethe, Nils Tore
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Peersen, Kari
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Fagerland, Morte ...
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Sverre, Elise
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Jensen, Elena Pr ...
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visa fler...
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Lindberg, Morten
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Gjertsen, Erik
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Gullestad, Lars
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Perk, Joep, 1945 ...
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Dammen, Toril
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Bergan, Stein
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Husebye, Einar
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Otterstad, Jan E ...
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Munkhaugen, John
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visa färre...
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European Heart J ...
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