Trends, geographical variation and factors associated with the use of anti-VEGF intravitreal injections in Portugal (2013–2018): a retrospective analysis of administrative data

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Rocha, João VictorNOVA University Lisbon, Portugal (author)

Trends, geographical variation and factors associated with the use of anti-VEGF intravitreal injections in Portugal (2013–2018): a retrospective analysis of administrative data

Article/chapterEnglish2022

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2022-04-06
BMJ Publishing Group Ltd,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:lnu-111261
https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-111261URI
https://doi.org/10.1136/bmjopen-2021-055478DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Title in Swedish: Trender, geografisk variation och faktorer förknippade med användningen av anti-VEGF intravitreala injektioner i Portugal (2013–2018): en retrospektiv analys av administrativa data
Aims The arrival of anti-vascular endothelial growth factor (anti-VEGF) therapies represented a treatment shift for several ophthalmological disorders and led to an increasing number of patients undergoing intravitreal injections. The aims of this observational study were to assess the expansion of anti-VEGF intravitreal injections in the Portuguese National Health System (NHS) and to identify factors correlated with geographical variations in episode rates.Methods Administrative database on discharge from Portuguese NHS hospitals was analysed for annual values and rates of intravitreal anti-VEGF injections at a national and regional level, between 2013 and 2018.Results The number of episodes of anti-VEGF treatment and patients treated increased 16% and 9% per year, respectively, between 2013 and 2018. During the study period around 72% of patients were treated in the Metropolitan areas of Lisbon and Porto and in the Central region. Intravitreal anti-VEGF treatment rates in 2018 were 560 per 100 000 population and presented high variability between municipalities. Higher anti-VEGF treatment rates at the municipality level were associated with shorter distances between their residence and the hospital. At the hospital level, higher ratio of ophthalmologists and higher organisational level were associated with higher anti-VEGF treatment rates.Conclusion The number of episodes and patients treated with anti-VEGF injections has been growing in recent years. Proximity to healthcare, more access to ophthalmologists and hospitals with higher organisational levels are associated with higher anti-VEGF treatment rates. Improving access is crucial to reduce regional discrepancies and ensure optimal treatment frequency, which may improve health outcomes.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Annan medicin och hälsovetenskap Övrig annan medicin och hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Other Medical and Health Sciences Other Medical and Health Sciences not elsewhere specified hsv//eng
Proliferative diabetic retinopathy
Retinal oedema
Choroidal neovascularisation
Retinal vein occlusion
anti-VEGF intravitreal injections
Neovascular age-related macular degeneration
Diabetic macular oedema
Optometry
Optometri
Medicin
Medicine

Added entries (persons, corporate bodies, meetings, titles ...)

Marques, Ana PatriciaNOVA University Lisbon, Portugal (author)
Macedo, António Filipe,Senior Lecturer,1976-Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Hållbar hälsa(Swepub:lnu)anmaag (author)
Afonso-Silva, MartaNovartis Farma Produtos Farmacêuticos SA, Portugal (author)
Laires, PedroNOVA University Lisbon, Portugal;Novartis Farma Produtos Farmacêuticos SA, Portugal (author)
Almeida, Ana SofiaNovartis Farma Produtos Farmacêuticos SA, Portugal (author)
Fernandes, JulietaNovartis Farma Produtos Farmacêuticos SA, Portugal (author)
Pardal, MarisaNovartis Farma Produtos Farmacêuticos SA, Portugal (author)
Santana, RuiNOVA University Lisbon, Portugal (author)
NOVA University Lisbon, PortugalInstitutionen för medicin och optometri (MEO) (creator_code:org_t)

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In:BMJ Open: BMJ Publishing Group Ltd12:42044-6055

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https://doi.org/10.1136/bmjopen-2021-055478Fulltext
http://bmjopen.bmj.com/content/12/4/e055478.abstractPublisher's fulltext
https://lnu.diva-portal.org/smash/get/diva2:1650972/FULLTEXT02.pdffulltext:print
https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-111261
https://doi.org/10.1136/bmjopen-2021-055478

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