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Inflammatory reacti...
Inflammatory reaction in the retina after focal non-convulsive status epilepticus in mice investigated with high resolution magnetic resonance and diffusion tensor imaging
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- Ahl, Matilda (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Clinical Epilepsy Research,Neurology, Lund,Department of Clinical Sciences, Lund
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- Avdic, Una (författare)
- Division of Clinical Neurophysiology, Sweden;Lund Universtity, Sweden
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- Chary, Karthik (författare)
- University of Eastern Finland, Finland
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- Shibata, Keisuke (författare)
- Division of Clinical Neurophysiology, Sweden;Lund Universtity, Sweden
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- Chugh, Deepti (författare)
- Lund University,Lunds universitet,Neurogenes och Cellterapi,Forskargrupper vid Lunds universitet,Neurogenesis and cell therapy,Lund University Research Groups
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- Linden Mickelsson, Pernilla (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Kettunen, Mikko (författare)
- University of Eastern Finland, Finland
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- Strandberg, Maria Compagno (författare)
- Lund University, Sweden
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- Englund Johansson, Ulrica (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nanostrukturer i neurala system,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Nanostructures in neural systems,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine
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- Sierra, Alejandra (författare)
- s, University of Eastern Finland, Finland
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- Ekdahl, Christine T (författare)
- Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk neurofysiologi,Institutionen för kliniska vetenskaper, Lund,Inflammation and Stemcell Therapy Group,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Neurophysiology,Department of Clinical Sciences, Lund,Lund University Research Groups
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- Lindbäck, Una (författare)
- Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Epilepsy Research. - : Elsevier. - 0920-1211 .- 1872-6844. ; 176
- Relaterad länk:
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https://doi.org/10.1...
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https://lnu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Pathophysiological consequences of focal non-convulsive status epilepticus (fNCSE) have been difficult to demonstrate in humans. In rats fNCSE pathology has been identified in the eyes. Here we evaluated the use of high-resolution 7 T structural T1-weighted magnetic resonance imaging (MRI) and 9.4 T diffusion tensor imaging (DTI) for detecting hippocampal fNCSE-induced retinal pathology ex vivo in mice. Seven weeks post-fNCSE, increased number of Iba1+ microglia were evident in the retina ipsilateral to the hemisphere with fNCSE, and morphologically more activated microglia were found in both ipsi- and contralateral retina compared to non-stimulated control mice. T1-weighted intensity measurements of the contralateral retina showed a minor increase within the outer nuclear and plexiform layers of the lateral retina. T1-weighted measurements were not performed in the ipsilateral retina due to technical difficulties. DTI fractional anisotropy(FA) values were discretely altered in the lateral part of the ipsilateral retina and unaltered in the contralateral retina. No changes were observed in the distal part of the optic nerve. The sensitivity of both imaging techniques for identifying larger retinal alteration was confirmed ex vivo in retinitis pigmentosa mice where a substantial neurodegeneration of the outer retinal layers is evident. With MR imaging a 50 % decrease in DTI FA values and significantly thinner retina in T1-weighted images were detected. We conclude that retinal pathology after fNCSE in mice is subtle and present bilaterally. High-resolution T1-weighted MRI and DTI independently did not detect the entire pathological retinal changes after fNCSE, but the combination of the two techniques indicated minor patchy structural changes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Optometry
- Optometri
- Medicinsk kemi
- Medical Chemistry
- Biomedical Sciences
- Biomedicinsk vetenskap
- DTI
- MRI
- non-convulsive status epilepticus
- Epilepsy
- Retina
- Inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ahl, Matilda
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Avdic, Una
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Chary, Karthik
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Shibata, Keisuke
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Chugh, Deepti
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Linden Mickelsso ...
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visa fler...
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Kettunen, Mikko
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Strandberg, Mari ...
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Englund Johansso ...
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Sierra, Alejandr ...
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Ekdahl, Christin ...
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Lindbäck, Una
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
- Artiklar i publikationen
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Epilepsy Researc ...
- Av lärosätet
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Linnéuniversitetet
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Lunds universitet