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  • Esser, Sarah P.Univ Duisburg Essen, Germany (author)

A predicted CRISPR-mediated symbiosis between uncultivated archaea

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Nature Publishing Group,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:lnu-123789
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-123789URI
  • https://doi.org/10.1038/s41564-023-01439-2DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • CRISPR spacers in DPANN archaea target putative essential genes in their episymbionts and could be a widespread occurrence across diverse archaeal lineages. CRISPR-Cas systems defend prokaryotic cells from invasive DNA of viruses, plasmids and other mobile genetic elements. Here, we show using metagenomics, metatranscriptomics and single-cell genomics that CRISPR systems of widespread, uncultivated archaea can also target chromosomal DNA of archaeal episymbionts of the DPANN superphylum. Using meta-omics datasets from Crystal Geyser and Horonobe Underground Research Laboratory, we find that CRISPR spacers of the hosts Candidatus Altiarchaeum crystalense and Ca. A. horonobense, respectively, match putative essential genes in their episymbionts' genomes of the genus Ca. Huberiarchaeum and that some of these spacers are expressed in situ. Metabolic interaction modelling also reveals complementation between host-episymbiont systems, on the basis of which we propose that episymbionts are either parasitic or mutualistic depending on the genotype of the host. By expanding our analysis to 7,012 archaeal genomes, we suggest that CRISPR-Cas targeting of genomes associated with symbiotic archaea evolved independently in various archaeal lineages.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rahlff, JaninaLinnéuniversitetet,Institutionen för biologi och miljö (BOM),Univ Duisburg Essen, Germany,Ctr Ecol & Evolut Microbial Model Syst EEMiS(Swepub:lnu)jaraad (author)
  • Zhao, WeishuUniv Rhode Isl, USA;Shanghai Jiao Tong Univ, China (author)
  • Predl, MichaelUniv Vienna, Austria (author)
  • Plewka, JuliaUniv Duisburg Essen, Germany (author)
  • Sures, KatharinaUniv Duisburg Essen, Germany (author)
  • Wimmer, FranziskaHelmholtz Ctr Infect Res HZI, Germany (author)
  • Lee, JaneyLawrence Berkeley Natl Lab, USA (author)
  • Adam, Panagiotis S.Univ Duisburg Essen, Germany (author)
  • McGonigle, JuliaUniv Utah, USA (author)
  • Turzynski, VictoriaUniv Duisburg Essen, Germany (author)
  • Banas, IndraUniv Duisburg Essen, Germany (author)
  • Schwank, KatrinUniv Duisburg Essen, Germany;Univ Regensburg, Germany (author)
  • Krupovic, MartUniv Paris Cite, France (author)
  • Bornemann, Till L. V.Univ Duisburg Essen, Germany (author)
  • Figueroa-Gonzalez, Perla AbigailUniv Duisburg Essen, Germany (author)
  • Jarett, JessicaLawrence Berkeley Natl Lab, USA (author)
  • Rattei, ThomasUniv Vienna, Austria (author)
  • Amano, YukiJapan Atom Energy Agcy, Japan (author)
  • Blaby, Ian K.Lawrence Berkeley Natl Lab, USA (author)
  • Cheng, Jan-FangLawrence Berkeley Natl Lab, USA (author)
  • Brazelton, William J.Univ Utah, USA (author)
  • Beisel, Chase L.Helmholtz Ctr Infect Res HZI, Germany;Univ Wurzburg, Germany (author)
  • Woyke, TanjaLawrence Berkeley Natl Lab, USA (author)
  • Zhang, YingUniv Rhode Isl, USA (author)
  • Probst, Alexander J.Univ Duisburg Essen, Germany (author)
  • Univ Duisburg Essen, GermanyInstitutionen för biologi och miljö (BOM) (creator_code:org_t)

Related titles

  • In:Nature Microbiology: Nature Publishing Group8, s. 1619-16332058-5276

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