SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:lnu-128434"
 

Search: id:"swepub:oai:DiVA.org:lnu-128434" > Estimated glomerula...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Damgaard, TobiasLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Linköping University, Sweden:Region Kalmar County, Sweden (author)

Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • Taylor & Francis Group,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:lnu-128434
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-128434URI
  • https://doi.org/10.1080/23744235.2024.2323002DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201835URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Region Kalmar County
  • Background: Only about 50% of intensive care unit (ICU) patients reach a free trough concentration above MIC (100% fT > MIC) of beta-lactam antibiotics. Although dose adjustments based on therapeutic drug monitoring (TDM) could be beneficial, TDM is not widely available. We investigated serum creatinine-based estimated GFR (eGFR) as a rapid screening tool to identify ICU patients at risk of insufficient exposure. Method: Ninety-three adult patients admitted to four ICUs in southeast Sweden treated with piperacillin/tazobactam, meropenem, or cefotaxime were included. Beta-lactam trough concentrations were measured. The concentration target was set to 100% fT > MICECOFF (2, 4, and 16 mg/L based on calculated free levels for meropenem, cefotaxime, and piperacillin, respectively). eGFR was primarily determined via Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and compared to three other eGFR equations. Data was analysed using logistic regression and receiver operative characteristic (ROC) curves. Results: With intermittent standard dosing, insufficient exposure was common in patients with a relative eGFR >= 48mL/min/1.73m(2) [85%, (45/53)], particularly when treated with cefotaxime [96%, (24/25)]. This eGFR cut-off had a sensitivity of 92% and specificity of 82% (AUC 0.871, p < 0.001) in identifying insufficient exposure. In contrast, patients with eGFR <48mL/min/1.73m(2) had high target attainment [90%, (36/40)] with a wide variability in drug exposure. There was no difference between the four eGFR equations (AUC 0.866-0.872, cut-offs 44-51 ml/min/1.73m(2)). Conclusion: Serum creatinine-based eGFR is a simple and widely available surrogate marker with potential for early identification of ICU patients at risk of insufficient exposure to piperacillin, meropenem, and cefotaxime.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Woksepp, HannaLinnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Region Kalmar County, Sweden,Linnaeus Univ, Sweden; Linnaeus Univ, Sweden; Linnaeus Univ, Sweden(Swepub:lnu)havoaa (author)
  • Brudin, LarsLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Linköping University, Sweden; Region Kalmar County, Sweden(Swepub:liu)larbr27 (author)
  • Bonnedahl, JonasLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Linköping University, Sweden:Region Kalmar County, Sweden(Swepub:liu)jonbo68 (author)
  • Nielsen, Elisabet I.Uppsala University, Sweden,Uppsala Univ, Sweden (author)
  • Schön, ThomasLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk mikrobiologi,Region Östergötland, Infektionskliniken i Östergötland,Linköping University, Sweden;Region Kalmar County, Sweden(Swepub:liu)thosc49 (author)
  • Hällgren, AnitaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,Linköping University, Sweden(Swepub:liu)aniha32 (author)
  • Linköpings universitetAvdelningen för inflammation och infektion (creator_code:org_t)

Related titles

  • In:Infectious Diseases: Taylor & Francis Group2374-42352374-4243

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Damgaard, Tobias
Woksepp, Hanna
Brudin, Lars
Bonnedahl, Jonas
Nielsen, Elisabe ...
Schön, Thomas
show more...
Hällgren, Anita
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Infectious Medic ...
Articles in the publication
Infectious Disea ...
By the university
Linnaeus University
Linköping University

Search outside SwePub

Wikipedia about the author:
Tobias_Damgaard
Damgaard, Tobias
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view