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Sökning: onr:"swepub:oai:DiVA.org:lnu-128696" > Protocol for the de...

  • Wilkinson, JackUniversity of Manchester, UK (författare)

Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • BMJ Publishing Group Ltd,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:lnu-128696
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-128696URI
  • https://doi.org/10.1136/bmjopen-2024-084164DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesise all RCTs that have been conducted on a given topic. While it is usual to assess methodological features of the RCTs in the process of undertaking a systematic review, it is not usual to consider whether the RCTs contain false data. Studies containing false data therefore go unnoticed and contribute to systematic review conclusions. The INveStigating ProblEmatic Clinical Trials in Systematic Reviews (INSPECT-SR) project will develop a tool to assess the trustworthiness of RCTs in systematic reviews of healthcare-related interventions.Methods and analysis The INSPECT-SR tool will be developed using expert consensus in combination with empirical evidence, over five stages: (1) a survey of experts to assemble a comprehensive list of checks for detecting problematic RCTs, (2) an evaluation of the feasibility and impact of applying the checks to systematic reviews, (3) a Delphi survey to determine which of the checks are supported by expert consensus, culminating in, (4) a consensus meeting to select checks to be included in a draft tool and to determine its format and (5) prospective testing of the draft tool in the production of new health systematic reviews, to allow refinement based on user feedback. We anticipate that the INSPECT-SR tool will help researchers to identify problematic studies and will help patients by protecting them from the influence of false data on their healthcare.Ethics and dissemination The University of Manchester ethics decision tool was used, and this returned the result that ethical approval was not required for this project (30 September 2022), which incorporates secondary research and surveys of professionals about subjects relating to their expertise. Informed consent will be obtained from all survey participants. All results will be published as open-access articles. The final tool will be made freely available.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Heal, CalvinUniversity of Manchester, UK (författare)
  • Antoniou, George AManchester University NHS Foundation Trust, UK;University of Manchester, UK (författare)
  • Flemyng, EllaEvidence Production and Methods Directorate Cochrane, UK (författare)
  • Alfirevic, ZarkoUniversity of Liverpool, UK (författare)
  • Avenell, AlisonUniversity of Aberdeen, UK (författare)
  • Barbour, GinnyMedical Journal of Australia, Australia (författare)
  • Brown, Nicholas,1960-Linnéuniversitetet,Institutionen för psykologi (PSY)(Swepub:lnu)nibrac (författare)
  • Carlisle, JohnTorbay Hospital, UK (författare)
  • Clarke, MikeQueen's University Belfast, UK (författare)
  • Dicker, PatrickRoyal College of Surgeons in Ireland, Ireland (författare)
  • Dumville, Jo CUniversity of Manchester, UK;Manchester Academic Health Science Centre, UK (författare)
  • Grey, AndrewUniversity of Auckland, New Zealand (författare)
  • Grohmann, StephEvidence Production and Methods Directorate Cochrane, UK (författare)
  • Gurrin, LyleUniversity of Melbourne, Australia (författare)
  • Hayden, Jill AlisonDalhousie University, Canada (författare)
  • Heathers, JamesSafeBeat Rx Inc, USA (författare)
  • Hunter, Kylie ElizabethUniversity of Sydney, Australia (författare)
  • Lasserson, TobyEvidence Production and Methods Directorate Cochrane, UK (författare)
  • Lam, EmilyIndependent Lay Member, UK (författare)
  • Lensen, SarahUniversity of Melbourne, Australia (författare)
  • Li, Tianjingniversity of Colorado, USA (författare)
  • Li, WentaoMonash University, Australia (författare)
  • Loder, ElizabethBMJ Publishing, UK;Brigham and Women's Hospital, USA (författare)
  • Lundh, AndreasCentre of Evidence-Based Medicine Odense, Denmark;Cochrane, Denmark;University of Southern Denmark, Denmark;Copenhagen University Hospita, Denmark (författare)
  • Meyerowitz-Katz, GideonUniversity of Wollongong, Australia (författare)
  • Mol, Ben WMonash University, Australia (författare)
  • O'Connell, Neil EBrunel University, UK;Brunel University, UK (författare)
  • Parker, LisaUniversity of Sydney, Australia (författare)
  • Redman, Barbara KNew York University Grossman School of Medicine, USA (författare)
  • Seidler, LeneUniversity of Sydney, Australia (författare)
  • Sheldrick, Kyle AUniversity of New South Wales, Australia (författare)
  • Sydenham, EmmaCochrane Central Production Service, UK (författare)
  • Torgerson, DavidUniversity of York, UK (författare)
  • van Wely, MadelonCochrane Gynaecology and Fertility Satellite and Cochrane Sexually Transmitted Infection Group, Netherlands;Amsterdam University Medical Center, Netherlands (författare)
  • Wang, RuiMonash University, Australia (författare)
  • Bero, LisaUniversity of Colorado, USA (författare)
  • Kirkham, Jamie JUniversity of Manchester, UK (författare)
  • University of Manchester, UKManchester University NHS Foundation Trust, UK;University of Manchester, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMJ Open: BMJ Publishing Group Ltd14:32044-6055

Internetlänk

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  • BMJ Open (Sök värdpublikationen i LIBRIS)

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