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Modulation of DNA R...
Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness
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- Zhao, Haiyu (författare)
- Karlsruhe Institute of Technology, Germany
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- Di Mauro, Giuseppe (författare)
- Karlsruhe Institute of Technology, Germany;University of Ferrara, Italy
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- Lungu-Mitea, Sebastian (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Karlsruhe Institute of Technology,University of Heidelberg,Karlsruhe Institute of Technology, Germany;University of Heidelberg, Germany;Swedish University of Agricultural Sciences, Sweden
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- Negrini, Pietro (författare)
- Karlsruhe Institute of Technology, Germany;University of Ferrara, Italy
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- Guarino, Andrea Maria (författare)
- Karlsruhe Institute of Technology, German;University of Naples “Federico II”, Italy
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- Frigato, Elena (författare)
- University of Ferrara, Italy
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- Braunbeck, Thomas (författare)
- University of Heidelberg, Germany
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- Ma, Hongju (författare)
- Karlsruhe Institute of Technology, Germany
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- Lamparter, Tilman (författare)
- Karlsruhe Institute of Technology, Germany
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- Vallone, Daniela (författare)
- Karlsruhe Institute of Technology, Germany
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- Bertolucci, Cristiano (författare)
- University of Ferrara, Italy
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- Foulkes, Nicholas S.; (författare)
- Karlsruhe Institute of Technology, Germany
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(creator_code:org_t)
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- Cell Press, 2018
- 2018
- Engelska.
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Ingår i: Current Biology. - : Cell Press. - 0960-9822 .- 1879-0445. ; 28:20, s. 3229-3243
- Relaterad länk:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- How the environment shapes the function and evolution of DNA repair systems is poorly understood. In a comparative study using zebrafish and the Somalian blind cavefish, Phreatichthys andruzzii, we reveal that during evolution for millions of years in continuous darkness, photoreactivation DNA repair function has been lost in P. andruzzii. We demonstrate that this loss results in part from loss-of-function mutations in pivotal DNA-repair genes. Specifically, C-terminal truncations in P. andruzzii DASH and 6-4 photolyase render these proteins predominantly cytoplasmic, with consequent loss in their functionality. In addition, we reveal a general absence of light-, UV-, and ROS-induced expression of P. andruzzii DNA-repair genes. This results from a loss of function of the D-box enhancer element, which coordinates and enhances DNA repair in response to sunlight. Our results point to P. andruzzii being the only species described, apart from placental mammals, that lacks the highly evolutionary conserved photoreactivation function. We predict that in the DNA repair systems of P. andruzzii, we may be witnessing the first stages in a process that previously occurred in the ancestors of placental mammals during the Mesozoic era.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- Evolutionary Biology
- Evolutionsbiologi
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Zhao, Haiyu
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Di Mauro, Giusep ...
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Lungu-Mitea, Seb ...
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Negrini, Pietro
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Guarino, Andrea ...
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Frigato, Elena
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Braunbeck, Thoma ...
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Ma, Hongju
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Lamparter, Tilma ...
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Vallone, Daniela
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Bertolucci, Cris ...
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Foulkes, Nichola ...
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