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The toxicity of rib...
The toxicity of ribbon worms: alpha-nemertides or tetrodotoxin, or both?
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- Andersson, Håkan S., 1967- (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC,Linnaeus Univ, Ctr Biomat Chem, Dept Chem & Biomed Sci, Norra Vagen 49, S-39234 Kalmar, Sweden.,Univ Gothenburg, Dept Biol & Environm Sci, Box 463, S-40530 Gothenburg, Sweden.
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- Jacobsson, Erik (författare)
- Uppsala universitet,Farmakognosi,Uppsala University,Department of Pharmacognosy
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- Eriksson, Camilla (författare)
- Uppsala universitet,Farmakognosi,Uppsala University,Department of Pharmacognosy
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- Hedström, Martin (författare)
- Lund University,Department of Biotechnology,Lund Univ, Dept Biotechnol, Box 118, S-22100 Lund, Sweden.
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- Seth, Henrik (författare)
- University of Gothenburg,Department of Biology and Environmental Sciences
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- Sundberg, Per (författare)
- University of Gothenburg,Department of Biology and Environmental Sciences,Univ Gothenburg, Dept Biol & Environm Sci, Box 463, S-40530 Gothenburg, Sweden.
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- Rosengren, K. Johan (författare)
- University of Queensland,School of Biomedical Sciences,Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
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- Strand, Malin (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,ARTDATABANKEN,Swedish Species Information Centre,Uppsala University,Univ Gothenburg, Dept Biol & Environm Sci, Box 463, S-40530 Gothenburg, Sweden.;Swedish Univ Agr Sci, Swedish Species Informat Ctr, Backlosavagen 10, S-75651 Uppsala, Sweden.,Sven Lovén Centre for Marine Sciences
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- Göransson, Ulf, 1970- (författare)
- Uppsala universitet,Farmakognosi,Uppsala University,Department of Pharmacognosy
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(creator_code:org_t)
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- 2016-12-14
- 2016
- Engelska.
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Ingår i: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 82:Supplement 1
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The marine ribbon worms (nemerteans) are predators which capture their prey by everting a proboscis carrying a mixture of toxins which brings on rapid paralysis [1]. Moreover, ribbon worms have a thick layer of epidermal mucus of similar constitution. Tetrodotoxin (TTX) has been identified as one of these toxins [2]. The extreme toxicity of TTX (lethal by ingestion of 0.5-2 mg) is due to its ability to block voltage-gated sodium channels. Although several bacterial species (among these Vibrio sp.) have been linked to its synthesis, the biogenic origin and biosynthesis is unclear. One hypothesis is that TTX production occurs in a symbiotic relationship with its host, in this case the ribbon worm [3]. We have made significant effort to identify TTX in a setup for production through the cultivation of Vibrio alginolyticus in nutrient broth infused with mucus from the ribbon worm Lineus longissimus. Toxicity was demonstrated by fraction injections into shore crabs, but no TTX was found, and it could be shown conclusively that toxicity was unrelated to TTX and the Vibrio culture itself, and rather a constituent of the ribbon worm mucus [4]. The following studies led us to the discovery of a new class of peptides, the alpha-nemertides, in the mucus of the ribbon worms, which could be directly linked to the toxic effects. A literature review of the available evidence for TTX in ribbon worms show that the evidence in most cases are indirect, although notable exceptions exist. This points to the necessity to further investigate the presence and roles of TTX and alpha-nemertides in ribbon worms.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Medicinsk kemi
- Medical Chemistry
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Andersson, Håkan ...
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Jacobsson, Erik
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Eriksson, Camill ...
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Hedström, Martin
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Seth, Henrik
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Sundberg, Per
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Rosengren, K. Jo ...
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Strand, Malin
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Göransson, Ulf, ...
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