Experimental Assessment of the Environmental Fate and Effects of Triazoles and Benzotriazole

The environmental fate and effects of triazoles and benzotriazoles are of concern within the context of chemical regulation. As part of an intelligent testing strategy, experimental tests were performed on endpoints that are relevant for risk assessment. The experimental tests included the assessment of eco-toxicity to an alga, a daphnid and zebrafish embryos, and the assessment of ready biodegradability. Triazole and benzotriazole compounds were selected for testing, based on existing toxicity data for vertebrate and invertebrate species, as well as on the principal component analysis of molecular descriptors aimed at selecting the minimum number of test compounds in order to maximise the chemical domain spanned for both compound classes. The experimental results show that variation in the toxicities of triazoles and benzotriazole across species was relatively minor; in general, the largest factor was approximately 20. The study conducted indicated that triazoles are not readily biodegradable.

NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
algae
aquatic toxicity
benzotriazoles
daphnids
ready biodegradability
triazoles
zebrafish embryos
Miljövetenskap
Environmental Science

Kolar, BorisPubl Hlth Inst Maribor, Slovenia (författare)
Arnus, LovroPubl Hlth Inst Maribor, Slovenia (författare)
Papa, EsterUniv Insubria, Italy (författare)
Kovarich, SimonaUniv Insubria, Italy (författare)
Sahlin, UllrikaLinnéuniversitetet,Institutionen för biologi och miljö (BOM)(Swepub:lnu)ulsaaa (författare)
Peijnenburg, WillieNatl Inst Publ Hlth & Environm RIVM, Netherlands ; Leiden Univ, Netherlands (författare)
Publ Hlth Inst Maribor, SloveniaUniv Insubria, Italy (creator_code:org_t)

Ingår i:ATLA (Alternatives to Laboratory Animals): SAGE Publications41:1, s. 65-750261-1929
Ingår i:Alternatives to Laboratory Animals: SAGE Publications41:1, s. 65-752632-3559

Av författaren/redakt...: Durjava, Mojca K ...; Kolar, Boris; Arnus, Lovro; Papa, Ester; Kovarich, Simona; Sahlin, Ullrika; visa fler...; Peijnenburg, Wil ...; visa färre...

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