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The association bet...
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Borghi, ClaudioUniversity of Bologna, Italy
(author)
The association between blood pressure and lipid levels in Europe : European study on cardiovascular risk prevention and management in usual daily practice
- Article/chapterEnglish2016
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LIBRIS-ID:oai:DiVA.org:lnu-58082
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-58082URI
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https://doi.org/10.1097/HJH.0000000000001078DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Objectives:Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries.Methods:Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (ClinicalTrials.gov identifier: NCT00882336). Associations between BP and lipid levels in patients free from cardiovascular disease and with at least one major cardiovascular disease risk factor (N=7641) were assessed using linear regression analyses.Results:Overall, 72.8 and 64.8% of patients had hypertension and dyslipidaemia, respectively; 47.0% had both conditions. Regression coefficients (95% confidence interval) for the associations of LDL cholesterol, non-HDL cholesterol, total cholesterol and apolipoprotein B levels with SBP, adjusted for age, sex and BMI, were 0.93mmHg/mmol per l (0.54-1.31), 1.07mmHg/mmol per l (0.73-1.40), 1.02mmHg/mmol per l (0.69-1.35) and 4.94mmHg/g per l (3.43-6.46), respectively. The corresponding values (95% confidence interval) for the associations with DBP were 0.96mmHg/mmol per l (0.73-1.19), 0.95mmHg/mmol per l (0.75-1.15), 0.87mmHg/mmol per l (0.67-1.07) and 4.33mmHg/g per l (3.42-5.23), respectively. Most of these associations remained significant whether patients were treated with statins or not.Conclusion:Small but statistically significant associations between lipid levels and BP were observed in a large, multinational European population. Further research is warranted to assess the causality of this association and its implications on the management of patients with both hypertension and dyslipidaemia.
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Rodriguez-Artalejo, FernandoUniv Autonoma Madrid IdiPaz, Spain ; Inst Salud Carlos III, Spain
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De Backer, GuyUniv Ghent, Belgium
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Dallongeville, JeanUniv Lille Nord France, France
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Medina, JesúsAstraZeneca Farmaceut Spain, Spain
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Guallar, EliseoJohns Hopkins Bloomberg Sch Publ Hlth, USA ; Johns Hopkins Bloomberg Sch Publ Hlth, USA
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Perk, JoepLinnéuniversitetet,Institutionen för hälso- och vårdvetenskap (HV)(Swepub:lnu)jpejo
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Banegas, José R.Univ Autonoma Madrid IdiPaz, Spain ; Inst Salud Carlos III, Spain
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Tubach, FlorenceHop Bichat Claude Bernard, France ; ECEVE, France ; Univ Paris Diderot, France
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Roy, CarineHop Bichat Claude Bernard, France ; ECEVE, France ; Hop Bichat Claude Bernard, France
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Halcox, Julian P.Swansea Univ, UK
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University of Bologna, ItalyUniv Autonoma Madrid IdiPaz, Spain ; Inst Salud Carlos III, Spain
(creator_code:org_t)
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In:Journal of Hypertension34:11, s. 2155-21630263-63521473-5598
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Rodriguez-Artale ...
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De Backer, Guy
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Dallongeville, J ...
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Medina, Jesús
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Guallar, Eliseo
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Perk, Joep
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Banegas, José R.
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Tubach, Florence
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Roy, Carine
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