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Sökning: onr:"swepub:oai:DiVA.org:lnu-60954" > High serum CXCL10 i...

  • Otterdal, KariOslo University Hospital Rikshospitalet, Norway (författare)

High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:lnu-60954
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-60954URI
  • https://doi.org/10.1016/j.cyto.2016.05.006DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: The pathophysiological hallmark of Rickettsia conorii (R. conorii) infection comprises infection of endothelial cells with perivascular infiltration of T-cells and macrophages. Although interferon (IFN)-γ-induced protein 10 (IP-10)/CXCL10 is induced during vascular inflammation, data on CXCL10 in R. conorii infection is scarce.METHODS: Serum CXCL10 was analyzed in two cohorts of southern European patients with R. conorii infection using multiplex cytokine assays. The mechanism of R. conorii-induced CXCL10 release was examined ex vivo using human whole blood interacting with endothelial cells.RESULTS: (i) At admission, R. conorii infected patients had excessively increased CXCL10 levels, similar in the Italian (n=32, ∼56-fold increase vs controls) and the Spanish cohort (n=38, ∼68-fold increase vs controls), followed by a marked decrease after recovery. The massive CXCL10 increase was selective since it was not accompanied with similar changes in other cytokines. (ii) Heat-inactivated R. conorii induced a marked CXCL10 increase when whole blood and endothelial cells were co-cultured. Even plasma obtained from R. conorii-exposed whole blood induced a marked CXCL10 release from endothelial cells, comparable to the levels found in serum of R. conorii-infected patients. Bacteria alone did not induce CXCL10 production in endothelial cells, macrophages or smooth muscle cells.CONCLUSIONS: We show a massive and selective serum CXCL10 response in R. conorii-infected patients, likely reflecting release from infected endothelial cells characterized by infiltrating T cells and monocytes. The CXCL10 response could contribute to T-cell infiltration within the infected organ, but the pathologic consequences of CXCL10 in clinical R. conorii infection remain to be defined.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Portillo, AránzazuHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain (författare)
  • Astrup, ElisabethOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway (författare)
  • Ludviksen, JudithResearch Laboratory Nordland Hospital, Norway (författare)
  • Davì, GiovanniUniversity of Chieti, Italy (författare)
  • Holm, SverreOslo University Hospital Rikshospitalet, Norway ; Hospital for Rheumatic Diseases, Norway (författare)
  • Santilli, FrancescaUniversity of Chieti, Italy (författare)
  • Vitale, GiustinaUniversity of Palermo, Italy (författare)
  • Raoult, DidierUniversité de la Mediterranée, France (författare)
  • Olano, Juan PUniversity of Texas Medical Branch, USA (författare)
  • Schjalm, CamillaUniversity of Oslo, Norway ; Oslo University Hospital Rikshospitalet, Norway (författare)
  • Halvorsen, BenteOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway (författare)
  • Oteo, José AHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain (författare)
  • Mollnes, Tom EirikUniversity of Oslo, Norway ; Research Laboratory Nordland Hospital, Norway ; Oslo University Hospital Rikshospitalet, Norway ; University of Tromsø, Norway ; Norwegian University of Science and Technology, Norway (författare)
  • Aukrust, PålOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway (författare)
  • Nilsson, Per H.,1980-Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway(Swepub:lnu)enipe (författare)
  • Oslo University Hospital Rikshospitalet, NorwayHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cytokine: Elsevier BV83, s. 269-2741043-46661096-0023

Internetlänk

Hitta via bibliotek

  • Cytokine (Sök värdpublikationen i LIBRIS)

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