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High serum CXCL10 i...
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Otterdal, KariOslo University Hospital Rikshospitalet, Norway
(författare)
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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Elsevier BV,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:lnu-60954
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-60954URI
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https://doi.org/10.1016/j.cyto.2016.05.006DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: The pathophysiological hallmark of Rickettsia conorii (R. conorii) infection comprises infection of endothelial cells with perivascular infiltration of T-cells and macrophages. Although interferon (IFN)-γ-induced protein 10 (IP-10)/CXCL10 is induced during vascular inflammation, data on CXCL10 in R. conorii infection is scarce.METHODS: Serum CXCL10 was analyzed in two cohorts of southern European patients with R. conorii infection using multiplex cytokine assays. The mechanism of R. conorii-induced CXCL10 release was examined ex vivo using human whole blood interacting with endothelial cells.RESULTS: (i) At admission, R. conorii infected patients had excessively increased CXCL10 levels, similar in the Italian (n=32, ∼56-fold increase vs controls) and the Spanish cohort (n=38, ∼68-fold increase vs controls), followed by a marked decrease after recovery. The massive CXCL10 increase was selective since it was not accompanied with similar changes in other cytokines. (ii) Heat-inactivated R. conorii induced a marked CXCL10 increase when whole blood and endothelial cells were co-cultured. Even plasma obtained from R. conorii-exposed whole blood induced a marked CXCL10 release from endothelial cells, comparable to the levels found in serum of R. conorii-infected patients. Bacteria alone did not induce CXCL10 production in endothelial cells, macrophages or smooth muscle cells.CONCLUSIONS: We show a massive and selective serum CXCL10 response in R. conorii-infected patients, likely reflecting release from infected endothelial cells characterized by infiltrating T cells and monocytes. The CXCL10 response could contribute to T-cell infiltration within the infected organ, but the pathologic consequences of CXCL10 in clinical R. conorii infection remain to be defined.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Portillo, AránzazuHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain
(författare)
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Astrup, ElisabethOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
(författare)
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Ludviksen, JudithResearch Laboratory Nordland Hospital, Norway
(författare)
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Davì, GiovanniUniversity of Chieti, Italy
(författare)
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Holm, SverreOslo University Hospital Rikshospitalet, Norway ; Hospital for Rheumatic Diseases, Norway
(författare)
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Santilli, FrancescaUniversity of Chieti, Italy
(författare)
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Vitale, GiustinaUniversity of Palermo, Italy
(författare)
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Raoult, DidierUniversité de la Mediterranée, France
(författare)
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Olano, Juan PUniversity of Texas Medical Branch, USA
(författare)
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Schjalm, CamillaUniversity of Oslo, Norway ; Oslo University Hospital Rikshospitalet, Norway
(författare)
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Halvorsen, BenteOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
(författare)
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Oteo, José AHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain
(författare)
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Mollnes, Tom EirikUniversity of Oslo, Norway ; Research Laboratory Nordland Hospital, Norway ; Oslo University Hospital Rikshospitalet, Norway ; University of Tromsø, Norway ; Norwegian University of Science and Technology, Norway
(författare)
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Aukrust, PålOslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway
(författare)
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Nilsson, Per H.,1980-Oslo University Hospital Rikshospitalet, Norway ; University of Oslo, Norway(Swepub:lnu)enipe
(författare)
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Oslo University Hospital Rikshospitalet, NorwayHospital San Pedro-Center of Biomedical Research from La Rioja (CIBIR), Spain
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cytokine: Elsevier BV83, s. 269-2741043-46661096-0023
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Otterdal, Kari
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Portillo, Aránza ...
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Astrup, Elisabet ...
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Ludviksen, Judit ...
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Davì, Giovanni
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Holm, Sverre
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Santilli, France ...
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Vitale, Giustina
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Raoult, Didier
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Olano, Juan P
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Schjalm, Camilla
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Halvorsen, Bente
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Oteo, José A
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Mollnes, Tom Eir ...
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Aukrust, Pål
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Nilsson, Per H., ...
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