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A rapid and transie...
A rapid and transient innate immune response to avian influenza infection in mallards
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- Helin, Anu S. (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden
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- Wille, Michelle (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden
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- Atterby, Clara (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University, Sweden
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- Järhult, Josef D., 1975- (författare)
- Uppsala universitet,Infektionssjukdomar,Uppsala University, Sweden
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- Waldenström, Jonas, 1975- (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden
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- Chapman, Joanne R. (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Univ Kansas, USA,Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden; Department of Molecular Biosciences, University of Kansas, Lawrence, USA
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Molecular Immunology. - : Elsevier. - 0161-5890 .- 1872-9142. ; 95, s. 64-72
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The vertebrate innate immune system provides hosts with a rapid, non-specific response to a wide range of invading pathogens. However, the speed and duration of innate responses will be influenced by the co-evolutionary dynamics of specific host-pathogen combinations. Here, we show that low pathogenic avian influenza virus (LPAI) subtype H1N1 elicits a strong but extremely transient innate immune response in its main wildlife reservoir, the mallard (Anas platyrhynchos). Using a series of experimental and methodological improvements over previous studies, we followed the expression of retinoic acid inducible gene 1 (RIG-I) and myxovirus resistance gene (Mx) in mallards semi-naturally infected with low pathogenic H1N1. One day post infection, both RIG-I and Mx were significantly upregulated in all investigated tissues. By two days post infection, the expression of both genes had generally returned to basal levels, and remained so for the remainder of the experiment. This is despite the fact that birds continued to actively shed viral particles throughout the study period. We additionally show that the spleen plays a particularly active role in the innate immune response to LPAI. Waterfowl and avian influenza viruses have a long co-evolutionary history, suggesting that the mallard innate immune response has evolved to provide a minimum effective response to LPAIs such that the viral infection is brought under control while minimising the damaging effects of a sustained immune response.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Anas platyrhynchos
- Zoonotic disease
- Avian disease
- Gene expression
- Retinoic acid inducible gene 1 RIG-I
- Myxovirus resistance gene Mx
- Influenza A virus
- LPAI
- HPAI
- Ecoimmunology
- Tolerance
- Zoonotisk ekologi
- Zoonotic Ecology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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