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Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis

Shahini, Negar (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
Ueland, Thor (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
Auensen, Andreas (författare)
Univ Oslo, Norway;Oslo Univ Hosp, Norway
visa fler...
Michelsen, Annika E. (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
Ludviksen, Judith K. (författare)
Nordland Hosp, Norway
Hussain, Amjad, I (författare)
Univ Oslo, Norway;Oslo Univ Hosp, Norway
Pettersen, Kjell, I (författare)
Oslo Univ Hosp, Norway
Aakhus, Svend (författare)
Norwegian Univ Sci & Technol, Norway
Espeland, Torvald (författare)
Norwegian Univ Sci & Technol, Norway;St Olays Hosp, Norway
Lunde, Ida G. (författare)
Univ Oslo, Norway;Oslo Univ Hosp, Norway
Kirschfink, Michael (författare)
Heidelberg Univ, Germany
Nilsson, Per H., 1980- (författare)
Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Avancerade material,Univ Oslo, Norway;Oslo Univ Hosp, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
Mollnes, Tom Eirik (författare)
Nordland Hosp, Norway;Univ Tromsö, Norway;Norwegian Univ Sci & Technol, Norway
Gullestad, Lars (författare)
Univ Oslo, Norway
Aukrust, Pal (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
Yndestad, Arne (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
Louwe, Mieke C. (författare)
Oslo Univ Hosp, Norway;Univ Oslo, Norway
visa färre...
 (creator_code:org_t)
2019-10-01
2019
Engelska.
Ingår i: Journal of Immunology. - : American Association of Immuologists. - 0022-1767 .- 1550-6606. ; 203:7, s. 1973-1980
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Inflammation is involved in initiation and progression of aortic stenosis (AS). However, the role of the complement system, a crucial component of innate immunity in AS, is unclear. We hypothesized that circulating levels of complement factor B (FB), an important component of the alternative pathway, are upregulated and could predict outcome in patients with severe symptomatic AS. Therefore, plasma levels of FB, Bb, and terminal complement complex were analyzed in three cohorts of patients with severe symptomatic AS and mild-to-moderate or severe asymptomatic AS (population 1, n = 123; population 2, n = 436; population 3, n = 61) and in healthy controls by enzyme immunoassays. Compared with controls, symptomatic AS patients had significantly elevated levels of FB (2.9- and 2.8-fold increase in population 1 and 2, respectively). FB levels in symptomatic and asymptomatic AS patients were comparable (population 2 and 3), and in asymptomatic patients FB correlated inversely with valve area. FB levels in population 1 and 2 correlated with terminal complement complex levels and measures of systemic inflammation (i.e., CRP), cardiac function (i.e., NT-proBNP), and cardiac necrosis (i.e., Troponin T). High FB levels were significantly associated with mortality also after adjusting for clinical and biochemical covariates (hazard ratio 1.37; p = 0.028, population 2). Plasma levels of the Bb fragment showed a similar pattern in relation to mortality. We concluded that elevated levels of FB and Bb are associated with adverse outcome in patients with symptomatic AS. Increased levels of FB in asymptomatic patients suggest the involvement of FB from the early phase of the disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Immunologi
Immunology

Publikations- och innehållstyp

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