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Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics
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- Mohebnasab, Maedeh (author)
- Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA
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- Eriksson, Oskar, 1984- (author)
- Uppsala universitet,Klinisk immunologi
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- Persson, Barbro (author)
- Uppsala universitet,Klinisk immunologi
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- Sandholm, Kerstin (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC,Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden
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- Mohlin, Camilla, 1972- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC,Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden
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- Huber-Lang, Markus (author)
- Univ Hosp Ulm, Inst Clin & Expt Trauma Immunol, Ulm, Germany
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- Keating, Brendan J. (author)
- Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA
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- Nilsson Ekdahl, Kristina (author)
- Uppsala universitet,Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC,Klinisk immunologi,Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden
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- Nilsson, Bo (author)
- Uppsala universitet,Klinisk immunologi
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(creator_code:org_t)
- 2019-11-08
- 2019
- English.
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In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 10, s. 1-13
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Abstract
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- Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- clinical trial
- laboratory investigation
- immunoassays
- functional assays
- CV%
- Immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Mohebnasab, Maed ...
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Eriksson, Oskar, ...
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Persson, Barbro
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Sandholm, Kersti ...
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Mohlin, Camilla, ...
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Huber-Lang, Mark ...
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Keating, Brendan ...
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Nilsson Ekdahl, ...
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Nilsson, Bo
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Linnaeus University
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Uppsala University