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Hormonal replacemen...
Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized placebo-controlled trial
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- Stening, Kent, 1968- (author)
- Linköpings universitet,Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap, HV,Department of Experimental and Clinical Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Health and Caring Sciences, Linnaeus University, Kalmar, Sweden,Cellbiologi,Hälsouniversitetet
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- Eriksson, Olle (author)
- Linköpings universitet,Statistik,Filosofiska fakulteten
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- Henriksson, Karl-Gösta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Rehabiliteringsmedicin,Hälsouniversitetet,Smärt- och rehabiliteringscentrum
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- Brynhildsen, Jan, 1962- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Lindh-Åstrand, Lotta (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Berg, Göran (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Hammar, Mats (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Amandusson, Åsa (author)
- Uppsala universitet,Klinisk neurofysiologi,Uppsala University
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- Blomqvist, Anders (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2010-11-14
- 2011
- English.
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In: Rheumatology. - London : Oxford univesity press. - 1462-0324 .- 1462-0332. ; 50:3, s. 544-551
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives. FM is a condition that preferentially affects women. Sex hormones, and in particular oestrogens, have been shown to affect pain processing and pain sensitivity, and oestrogen deficit has been considered a potentially promoting factor for FM. However, the effects of oestrogen treatment in patients suffering from FM have not been studied. Here, we examined the effect of transdermal oestrogen substitution treatment on experimental as well as self-estimated pain in women suffering from FM.Methods. Twenty-nine post-menopausal women were randomized to either 8 weeks of treatment with transdermal 17β-oestradiol (50 µg/day) or placebo according to a double-blind protocol. A self-estimation of pain, a set of quantitative sensory tests measuring thresholds to temperature, thermal pain, cold pain and pressure pain, and a cold pressor test were performed on three occasions: before treatment, after 8 weeks of treatment and 20 weeks after cessation of treatment.Results. Hormonal replacement treatment significantly increased serum oestradiol levels as expected (P < 0.01). However, no differences in self-estimated pain were seen between treatment and placebo groups, nor were there any differences between the two groups regarding the results of the quantitative sensory tests or the cold pressor test at any of the examined time points.Conclusion. Eight weeks of transdermal oestradiol treatment does not influence perceived pain, pain thresholds or pain tolerance as compared with placebo treatment in post-menopausal women suffering from FM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Rheumatology
- Reumatologi
- Health and Caring Sciences
- Hälsovetenskap
- Biomedical Sciences
- Biomedicinsk vetenskap
- Vårdvetenskap
- Caring Science
- Oestrogen
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stening, Kent, 1 ...
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Eriksson, Olle
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Henriksson, Karl ...
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Brynhildsen, Jan ...
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Lindh-Åstrand, L ...
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Berg, Göran
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Hammar, Mats
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Amandusson, Åsa
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Blomqvist, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Rheumatology
- By the university
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Linnaeus University
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Örebro University
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Uppsala University
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Linköping University